Glaucoma

A fixed combination of brinzolamide 1% and brimonidine 0.2% used twice a day lowers IOP significantly more than either drug alone and is as safe as either, according to results of a 6-month, Phase III study.

The European Commission has approved the eye drop suspension of brinzolamide 10 mg/mL and brimonidine tartrate 2 mg/mL to decrease elevated intraocular pressure (IOP) in adult patients who have open-angle glaucoma or ocular hypertension.

Acute glaucoma in mice is largely an inflammatory disease, and high intraocular pressure (IOP) causes vision loss by starting an inflammatory response similar to that caused by bacterial infections.

When detecting and evaluating the progression of glaucoma, Bruch's membrane opening-minimum rim width (BRO-MRW) may be the best predictor of the threshold of visual sensitivity and total deviation of visual field, according to a new study.

Diurnal IOP curves have limited value in clinical practice for patients with primary open-angle glaucoma (POAG), according to a newly published study.

Gonioscopy-assisted transluminal trabeculotomy is a circumferential trabeculotomy performed via a minimally invasive, ab interno approach. Results from follow-up of 6 to 12 months in a series of 85 adult eyes with uncontrolled glaucoma show high IOP lowering, along with a reduced need for medication.

When people sleep with their heads elevated 20 degrees, their nocturnal IOP is lower than when they sleep with their heads flat, finds a newly published study.

Increased blood pressure contributes to elevated IOP and possibly the development of glaucoma, according to the findings of a recent meta-analysis.

The Committee for Medicinal Products for Human Use (CHMP) of the European Medicines Agency (EMA) has issued a positive opinion for brinzolamide 10 mg/mL and brimonidine tartrate 2 mg/mL eye drops suspension (Simbrinza, Alcon) to decrease elevated intraocular pressure (IOP) in adult patients with open-angle glaucoma or ocular hypertension, for whom monotherapy provides insufficient IOP reduction.

Implantation of two trabecular micro-bypass devices (iStent inject, Glaukos) reduced intraocular pressure (IOP) at least as effectively as a fixed combination of latanoprost/timolol in patients who had open-angle glaucoma that was not controlled by one medication, according to a recent study.

Prof. Iester describes his recent study investigating whether the addition of a tear substitute would protect exposed corneal epithelial cells from damage.

A Phase II dose-ranging study has been initiated for Amakem Therapeutics? glaucoma drug candidate AMA0076, a highly potent, locally acting Rho Kinase (ROCK) inhibitor designed to reduce intraocular pressure (IOP) while minimizing common ROCK inhibitor side effects such as hyperaemia.

A supracilliary micro-stent, when implanted in conjunction with cataract surgery, substantially reduces intraocular pressure (IOP) with minimal complications in patients with open-angle glaucoma, according to researchers in Germany and the US.

Patients with refractory glaucoma in whom a proprietary glaucoma implant was placed needed significantly less adjunctive medication to experience success in treatment compared with those who received a proprietary glaucoma valve. However, fewer of those in the latter group had serious postoperative complications, according to recently published 3-year outcomes.

In this article, the authors describe their novel technique for penetrative trabeculectomy in primary open-angle glaucoma patients, called sutureless trabeculectomy.

Preservatives are an important component of topical multidose glaucoma medications. However, many glaucoma patients have symptoms of ocular surface disease (OSD), which can affect quality of life, treatment adherence and surgical outcomes. In this article, Prof. Baudouin offers straightforward steps to assess OSD and identify the patients most at risk.

The authors have sought to expand the concept of automated alternation flicker to improve detection of glaucomatous optic neuropathy and highlight their findings in this article.

Carbon dioxide laser assisted sclerectomy surgery (CLASS) is being used as an effective and safe, minimally invasive treatment for glaucoma. In this article, two surgeons at the forefront of research, development and implementation of this approach discuss this surgical option and its benefits for the ophthalmic market.

The combination of microinvasive glaucoma surgeries with cataract surgery may address a patient's cataract and glaucoma in one procedure.

Ultrasound circular cyclocoagulation is a non-invasive treatment for refractory glaucoma that is approved in Europe.

Primary congenital glaucoma is usually controlled with surgery, however, in a recent paper it has been demonstrated that long-term treatment with latanoprost 0.005% eyedrops is effective in about 30% of affected eyes.

Vitamin D deficiency may be a potential risk factor in the development of open-angle glaucoma (OAG), according to a recent study.

Repetitive activation of residual vision with training of the visual field borders and areas of residual vision can improve visual field defects caused by glaucoma and increase detection sensitivity, according to results from a randomized clinical trial.

SLT is a popular treatment option for glaucoma. In this article, Dr McAlinden discusses his recent paper that reviewed comparative studies from peer-reviewed journals, finding encouraging and reassuring results about SLT.

Corneal anterior segment imaging has emerged as a screening tool for refractive surgery, cataract and glaucoma. In this article, the authors discuss their recent study that identified a set of normative data to correct for sources of bias in pre-surgery screening.