August 1st 2025
The Global RDH12 Alliance unites inherited retinal disease advocacy groups including UK-based Eyes on the Future and the US-based RDH12 Fund for Sight
July 18th 2025
The platform, developed by University College London and Heidelberg Engineering, demonstrated accuracy and precision in early tests
June 3rd 2025
Insights from a genome-wide association study identify novel genetic loci
May 13th 2025
The company shared results from the AAVB-081 clinical programme and AAVB-039 preclinical programme at ARVO
May 6th 2025
Opus Genetics reveals promising 1-year results from OPGx-LCA5 gene therapy, showing sustained vision improvements in adults with LCA5 retinal degeneration.
When will gene therapy be ready for patients with age-related macular degeneration?
Antibody drug discovery company Novelty Nobility joins Johnson & Johnson JLABS Korea
The company's therapeutic candidates include a bispecific antibody to target vascular retinal diseases
Moorfields Eye Hospital INSIGHT research hub will collaborate with artificial intelligence development company Insitro
The partnership will use ocular imaging to build an AI foundation model and identify new genetic targets for degenerative diseases
First patient dosed in Phase 1/2 ASTRA study for Stargardt disease therapy SB-007 (SpliceBio)
SpliceBio continues to actively enroll patients in the ASTRA study and accompanying POLARIS trial
Study links new gender and genetic factors to Fuchs Endothelial Corneal Dystrophy
A large-scale study indicates women are more likely to develop the inherited corneal condition
EMA provides positive ATMP opinion for gene therapy products OCU410 and OCU410ST
The modifier gene therapies from Ocugen target geographic atrophy and Stargardt disease
Novel stem cell therapy restores corneal damage previously believed irreversible
The authors said their results provide strong support that cultivated autologous limbal epithelial cell transplantation is safe and feasible
Study demonstrates visual acuity improvements following gene therapy for AIPL1-associated inherited retinal dystrophies
Researchers indicated that paediatric patients with Leber congenital amaurosis experienced improvements in vision
GenSight Biologics shares efficacy and safety findings from REFLECT Phase III gene therapy trial
The company shared 5-year results for lenadogene nolparvovec (Lumevoq), administered unilaterally and bilaterally to patients with Leber Hereditary Optic Neuropathy
An accessible, free resource on genetic eye disease is changing patient education
Mariya Moosajee, MBBS, BSc, PhD, FRCOphth, discusses how Gene Vision is improving patients' lives on a global scale
Study indicates age and gender are factors in ocular gene therapy outcomes
Researchers from the University of Bristol recorded increased instances of inflammation in particular demographic groups
Ocugen, Inc. receives European Medicines Agency ATMP designation for new gene therapy OCU400
OCU400 is the first gene therapy from the biotechnology company to move forward into Phase 3 with a broad retinitis pigmentosa (RP) indication
Viralgen and Axovia Therapeutics enter partnership, target retinal dystrophy in Bardet-Biedl Syndrome
The lead gene therapy candidate, AXV-101, is expected to enter clinical development in mid-2025
RhyGaze announces $86 million in Series A financing for optogenetic vision restoration therapy candidate
The company, which has European headquarters in Basel, Switzerland, plans to use the funds for a non-interventional, observational study and a first-in-human clinical trial
ViGeneron receives rare paediatric disease designation from US FDA for retinitis pigmentosa gene therapy candidate VG901
ViGeneron, based in Munich, also received approval for dose escalation in the ongoing phase 1b clinical trial
International RESTORE study produces results of genetic therapy for Leber hereditary optic neuropathy
The RESTORE Study is the follow-up study of the RESCUE and REVERSE studies of lenadogene nolparvovec to treat vision loss from LHON
See the best of our print edition with the 2024 cover story roundup
Our top 10 print stories highlight the core content concepts we explored this year
A neurologist shares his warning about recurrent optic neuritis attacks and NMOSD
Ocular clues to a neurological conditions help clinicians understand neuromyelitis optica spectrum disorder (NMOSD)
AMD-HALT programme receives Eurostars grant for continued investigation of dry AMD gene therapy platform
Phenocell and Amarna Therapeutics were awarded the grant by Eureka’s Eurostars initiative, co-funded by the European Union
US FDA clears investigational new drug application for CRISPR/Cas13 RNA-editing therapy
HG202, by HuidaGene Therapeutics, is formulated for clinical use in treating neovascular age-related macular degeneration
Innovation and the clinician scientist
Collaboration and outside-the-box thinking present significant opportunities for science and industry
Ocuphire Pharma and Opus Genetics announce merger
The company also announced it will seek a strategic partner to continue development of APX3330, an oral small-molecule inhibitor of Ref-1 for the treatment of non-proliferative diabetic retinopathy.
Gene therapy for managing neovascular macular degeneration
Gene therapy for nAMD represents significant advancements in the treatment of retinal conditions
The latest genetic research from this summer’s retina conferences
Gene therapy was a major topic at the 2024 EURETINA and Retina Society meetings
Trinity team’s gene therapy offers promising glaucoma and AMD treatment
Research by investigators at Trinity College in Dublin, Ireland shows how the gene therapy conferred significant protection for retinal ganglion cells
Untangling the genetic secrets of retinoblastoma
Identifying all genetic culprits may improve diagnostics and prognoses
Aurion Biotech candidate AURN001 receives US Breakthrough Therapy Designation and Regenerative Medicine Advanced Therapy Designation
The US Food and Drug Administration issued designations for the allogeneic cell therapy candidate, a therapeutic for corneal oedema
Beacon Therapeutics treats first patient in global registration trial for X-linked retinitis pigmentosa therapeutic
XLRP often leads to blindness by middle age with no treatment options currently available
Paediatric case study suggests genetic syndrome link associated with ocular tumor
Investigators say the discovery highlights the importance of genetic consultation
New therapeutic targets, drug development for retinitis pigmentosa
Simply slowing disease progression is no longer enough