Vitamin D deficiency may be a risk factor for OAG

Vitamin D deficiency may be a potential risk factor in the development of open-angle glaucoma (OAG), according to a study recently published In Public Health Nutrition, which is the first to show an association between vitamin D status and OAG.

Researchers from the Yonsei University College of Medicine, Seoul, Republic of Korea, used data from 6,094 adult subjects randomly selected from 192 surveys in 131 locations in South Korea, from the Fifth Korean National Health and Nutrition Examination Survey conducted in 2010–2011. Using multivariate logistic regression, they examined the relationship between serum 25-hydroxyvitamin D [25(OH)D] and OAG after adjusting for traditional potential confounders. OAG was defined using the criteria of the International Society for Geographical and Epidemiological Ophthalmology.

The multivariate-adjusted odds ratio of OAG across quintiles of decreasing 25(OH)D were 1.26 (1.00 reference), 1.31 and 1.69 (P for quadratic trend P

These researchers concluded that there is a reverse J-shaped association between 25(OH)D levels and the risk of OAG, and that subjects with lower 25(OH)D levels had a significantly elevated risks of OAG.

For more information on this study, please click here.