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ZEISS Clinical Cases|

Heidelberg Engineering: Enhancing the Patient Journey

Opinion|Videos|January 24, 2025

Study Design for PULSAR and PHOTON Trials for Aflibercept 8 mg

Author(s)John Kitchens, MD, Richard Gale, PhD, MEd, BSc, MBChB, FRCP, FRCOphth, Michael W. Stewart, MD

Panelists discuss how the phase 3 PULSAR and PHOTON trials demonstrated the efficacy of aflibercept 8 mg through a design comparing 12- and 16-week dosing intervals to the aflibercept 2 mg standard 8-week dosing, with primary end points assessing noninferiority in visual acuity maintenance.

Episodes in this series

3 experts are featured in this series.

EP. 1 Evolution of Anti-VEGF Agents and Unmet Needs in Retinal Diseases

3 experts are featured in this series.

EP. 2 Advantages of the Molecular Structure of Aflibercept

3 experts are featured in this series.

EP. 3 Treat-and-Extend Strategy With Aflibercept

3 experts are featured in this series.

EP. 4 Assessing New Therapies for Retinal Diseases

3 experts are featured in this series.

EP. 5 Significance of the Higher Molar Dose of Aflibercept 8 mg

3 experts are featured in this series.

EP. 6 Study Design for PULSAR and PHOTON Trials for Aflibercept 8 mg

3 experts are featured in this series.

EP. 7 Patient Selection for Aflibercept 8 mg

3 experts are featured in this series.

EP. 8 Faricimab Molecular Design and Role of Ang-2

3 experts are featured in this series.

EP. 9 Outcomes with Raricimab and Choosing Between the New Therapies

3 experts are featured in this series.

EP. 10 Safety Profile of New Therapies

3 experts are featured in this series.

EP. 11 Perspectives on the Usefulness of Real-world Data

3 experts are featured in this series.

EP. 12 Strategies for Loading Dose Sse for Treatment-Naive and Switch Patients

3 experts are featured in this series.

EP. 13 Impact of Durable Therapies on Patients and Clinics and Monitoring Strategies

Video content above is prompted by the following:

Aflibercept 8 mg was evaluated in the PULSAR and PHOTON trials for neovascular age-related macular degeneration and diabetic macular edema. Could you briefly review the design of these trials?

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