Articles

The Committee for Medicinal Products for Human Use (CHMP) of the European Medicines Agency (EMA) has issued a positive opinion for brinzolamide 10 mg/mL and brimonidine tartrate 2 mg/mL eye drops suspension (Simbrinza, Alcon) to decrease elevated intraocular pressure (IOP) in adult patients with open-angle glaucoma or ocular hypertension, for whom monotherapy provides insufficient IOP reduction.

Taking vasodilators may increase the risk of developing early-stage age-related macular degeneration (AMD), according to a study published online.

Bromfenac ophthalmic solution 0.07% (Pro-Lensa, Bausch + Lomb) used once a day results in zero-to-trace (0–5 cells) cell severity in the anterior chamber following cataract surgery with implantation of a posterior chamber IOL, according to newly published research.

Dropper bottles are the delivery vehicle of choice of patients using autologous serum eye drops daily for severe ocular surface disorders, according to a newly published study.

Patients who have macular oedema secondary to branch retinal vein occlusion (BRVO) see improved anatomic and functional outcomes with combined intravitreal bevacizumab (IVB) and intravitreal triamcinolone acetate (IVT) therapy when it is delivered early in the disease process, according to the findings of recently published research.

Implantation of two trabecular micro-bypass devices (iStent inject, Glaukos) reduced intraocular pressure (IOP) at least as effectively as a fixed combination of latanoprost/timolol in patients who had open-angle glaucoma that was not controlled by one medication, according to a recent study.

Postoperative refractive outcome shifts toward myopia in patients being treated for rhegmatogenous retinal detachment (RRD) with the combination of phacoemulsification and pars plana vitrectomy, compared with patients who underwent combined surgery for other vitreoretinal pathologies

Radiused phacoemulsification tips were less efficient than non-radiused tips when used with torsional ultrasound (US), according to an experimental study.

Micropulse diode transscleral cyclophotocoagulation (TSCPC) lowers IOP consistently, predictably, and with minimal ocular complications, according to a recently published study.

A Phase II dose-ranging study has been initiated for Amakem Therapeutics? glaucoma drug candidate AMA0076, a highly potent, locally acting Rho Kinase (ROCK) inhibitor designed to reduce intraocular pressure (IOP) while minimizing common ROCK inhibitor side effects such as hyperaemia.

Scleral buckling or pars plana vitrectomy (PPV) can be used to treat rhegmatogenous retinal detachment (RD) associated with Beh?et's disease (BD), according to researchers in the Department of Ophthalmology, Zagazig University, Egypt.

A supracilliary micro-stent, when implanted in conjunction with cataract surgery, substantially reduces intraocular pressure (IOP) with minimal complications in patients with open-angle glaucoma, according to researchers in Germany and the US.

Patients with refractory glaucoma in whom a proprietary glaucoma implant was placed needed significantly less adjunctive medication to experience success in treatment compared with those who received a proprietary glaucoma valve. However, fewer of those in the latter group had serious postoperative complications, according to recently published 3-year outcomes.

The correlation between hyperglycaemia and retinopathy of prematurity (ROP) is significant, according to logistical regression analysis of gestational age and birth weight data in a recent study.

Recombinant human Nerve Growth Factor (rhNGF) may offer hope for patients with neurotrophic keratitis (NK), according to researchers in Milan, Italy, who presented preliminary data from a Phase I study at the annual meeting of the Association for Research in Vision and Ophthalmology.

A tetracycline-inducible Cre mouse line created specifically to study the retinal pigment epithelium (RPE) is suitable for Cre/lox-based gene activation and inactivation in adult RPE, which makes the mice suitable for long-term studies requiring conditional gene targeting.

Implantation of a capsular tension ring effectively reduces the percentage area of posterior capsular opacification (PCO) and the Nd:YAG laser capsulotomy rate in patients with highly myopic eyes, according to researchers in Albania and Turkey.

Cigarette smoking causes a temporary but significant increase in choroidal thickness, according to research conducted at the Department of Ophthalmology, Faculty of Medicine, Abant Izzet Baysal University, Bolu, Turkey.

The eXcellence in Ophthalmology Vision Award (XOVA) competition is accepting entries until 30 June.

This year, the Vision UK 2014 conference was to be held on Thursday 12 June at the Queen Elizabeth II conference centre in London, UK. Attendees can look forward to key opinion leaders discussing the UK Vision Strategy and emphasizing the initiatives that need to be implemented across the UK.

For a small percentage of patients who have macular holes, ocriplasmin injection represents an adequate treatment option; however, for most patients, pars plana vitrectomy will likely remain the treatment of choice.

In children, implantation of a multifocal IOL remains a topic of debate. With lacking evidence on post surgery outcomes and no head-to-head comparison of multifocal IOLs in children, this issue remains to be clarified. Therefore, the authors of this article were prompted to perform research in this area to address a number of concerns among paediatric ophthalmologists.

In this article, Dr Portaliou discusses a new multi-component adjustable lens that may be the answer paediatric ophthalmologists have been waiting for.

Determining the optimal IOL power for children is as much an art as a science.

Glaucoma, but not ageing, changes rapid contrast adaptation, which is vital to visual processing in natural visual environments, say researchers from Australia in a recent study.

Cyclosporine A (CSA) protects retinal ganglion cells (RGCs) against glutamate-induced excitotoxicty and should be tested to see whether its neuroprotective properties will work against RGC disorders, researchers recently reported

Oral diclofenac sufficiently manages pain after photorefractive keratectomy (PRK), and adding topical diclofenac 0.1% drops to a post-PRK oral diclofenac regimen does not add any additional pain-control benefit, according to recent research.

Intravitreal ranibizumab (IVR) stabilizes vision in patients with retinal angiomatous proliferation (RAP), according to researchers from Japan.

Novaliq GmbH is launching a Phase 1 study of its 0.05% clear cyclosporine solution (CyclASol) following European and US patent approval of the solution for the treatment of dry eye syndrome.

Endophthalmitis is most often caused by coagulase-negative Staphylococcus, and the antibiotics vancomycin and ceftazidime seem to perform well in treating it. That was one of the findings of a 25-year retrospective study conducted by Dr Ronald C. Gentile, of the New York Eye and Ear Infirmary, and his colleagues in New York City and San Antonio, Texas, USA.