The approach to lowering intraocular pressure reduces medication burden without risking graft rejection
Glaucoma is a leading cause of vision loss worldwide, and the risk of developing glaucoma is known to be higher for patients undergoing corneal transplant. To lower intraocular pressure (IOP) following corneal surgery, gonioscopy-assisted transluminal trabeculotomy (GATT) can be a safe and effective alternative to traditional procedures.
A retrospective analysis of patients who underwent GATT following prior corneal transplant produced data to support GATT’s efficacy.1 Oluwatosin Smith, MD, a physician at Glaucoma Associates of Texas, Dallas, and the study’s lead author, discussed GATT as a safe and efficient intervention. “If we look at the results in the study, we’ll see that many of those patients had a significant reduction in the number of medicines that they were on to control IOP after they had this procedure,” she said. A reduction in medication burden is significant for patients post corneal transplant, such as some participants who began the study while on 4 or more medications.
Study cohort demographics
The case series documented a group of 32 patients and 39 eyes, all patients with glaucoma and a history of prior corneal surgery (Figure 1). The authors recognised this as the largest group with those characteristics to undergo clinical review thus far.1 Patient age ranged from 24 to 94 years (mean 68.0 y); 44% of participants were female and 81% were Caucasian. Prior corneal surgical procedures included penetrating keratoplasty (59.0%), Descemet stripping endothelial keratoplasty (35.9%), Descemet membrane endothelial keratoplasty (2.6%) and deep anterior lamellar keratoplasty (2.6%). In most cases, GATT was performed as a standalone procedure. In one instance it was performed in combination with cataract extraction/intraocular lens insertion; in another, GATT was performed alongside goniosynechialysis. All GATT procedures were performed by physicians at Glaucoma Associates of Texas between January 2016 and December 2019.
Among the study cohort, 35 patients (89.7%) had 1 prior corneal surgery while 4 patients (10.3%) had multiple corneal surgeries (range: 2 to 7).1 Secondary open angle glaucoma was the most common (64.1%), followed by steroid-induced glaucoma (23.1%). Notably, patients with secondary open angle glaucoma did not have pre-existing glaucoma before their corneal transplants. At the 24-month visit, 20 eyes (51.3%) had completed follow-up data.
Results of GATT following corneal surgery
Dr Smith said that treating elevated IOP in eyes with glaucoma after corneal transplantation surgery is challenging, since surgeons must minimise potential insult to the corneal graft tissue. Following GATT, most patients saw a significant reduction in IOP, as well as reduced medication burden, at all postoperative time points (Figure 2). The study’s authors censored patients who required reoperation to control IOP (P<.001) from these figures, produced at the 24-month visit: at 24 months, IOP decreased from baseline of 30.9±11.5 to 13.9±4.7 mm Hg. Medications decreased from 4.2±1.0 medications at baseline to 0.6±1.0, and 88% of patients who completed the study remained on chronic topical steroids for graft maintenance.1
Following the procedure, 69% of eyes had at least one early complication. Postoperative complications noted at week 1 included hyphema (59%), corneal oedema (18%) and vitreous prolapse (1%). At month 1, 77% had no complications, 13% reported persistent hyphema, and 10% (4 eyes) reported corneal oedema. Between 3 and 9 months, 75% of eyes with cornea oedema resolved; the 1 eye with persistent oedema had corneal oedema before GATT surgery.
After undergoing GATT, 7 eyes required reoperation for uncontrolled glaucoma at a median of 8.5 months (range: 1.6-16.2). The cumulative proportion of eyes requiring further surgery to control IOP was 10.3% (95% CI, 80%-99%) at month 12, increasing to 20.3% (95% CI, 67%-94%) at 24 months following GATT.
Over the first postsurgical month, visual acuity decreased in all eyes (all P< 0.05); but the authors stated “these recovered at subsequent follow-up visits with 2-Snellen line improvements exceeding losses from month 3 to 36.”1 Among the 4 eyes with visual decrease from baseline at 12 months, 2 eyes deteriorated from wet AMD with clear corneas and 1 eye had a tube shunt with corneal decompensation and inflammation.
Given the safety and efficacy results of the GATT procedure in post-corneal transplant patients, Dr Smith reiterated the surgery as a suitable alternative for patients who have developed glaucoma following transplantation. GATT is especially prudent when applied in earlier stages of glaucoma development, she said, as part of an interventional approach. “There are patients who this is optimal for, usually people who don’t have a secondary angle closure. The reasons for their elevation in pressure could be related to prior surgery or having had a corneal transplant.” She said physicians should take note of GATT, in particular, when a drainage device may pose risk to transplanted tissue. “The benefit of having surgery without hardware in the eye is that you’re not leaving anything in the eye,” she said. “In the event that you have a
drainage implant, because it’s a foreign body, there’s a risk of graft failure, exposure of the implant device and possible complications of an infection.”
“For patients who have open angle glaucoma, we have to look at the risks versus benefits of doing a more traditional surgery,” Dr Smith continued. “When you have an option [such as GATT] where the risks are low and the benefits are great, then comparing the procedures encourages you to go ahead and consider GATT as an option.”
Oluwatosin U. Smith, MD | E: firstname.lastname@example.org
Oluwatosin U. Smith, MD. is an attending clinician and surgeon at Glaucoma Associates of Texas and a founding board member of the Cure Glaucoma Foundation.