Addressing endogenous endophthalmitis in patients

In endophthalmitis, the systemic anti-infective treatment specific to the infectious agent should always be used.

Reviewed by Dr Winfried M. K. Amoaku.

Endophthalmitis is a rare occurrence in ocular surgery but the percentage, no matter how small, remains unacceptable. Dr Winfried M. K. Amoaku, associate professor/reader in ophthalmology and Hon consultant ophthalmologist, University of Nottingham and Nottingham University Hospitals NHS Trust, Nottingham, United Kingdom, recently described the management protocol followed in the UK to treat older patients with endogenous endophthalmitis.

The endogenous form of the infection is exceedingly rare, occurs in 1 per 1 million cases annually and accounts for about 10% of all endophthalmitis. Intraocular infection occurs as the result of haematogenous spread from a distant non-ophthalmic source and may be bacterial, fungal, parasitic or viral.

Dr Amoaku explained that the patients most (but not exclusively) likely to develop endogenous endophthalmitis are immunocompromised, and include those with diabetes, systemic cancer and HIV, as well as those taking antineoplastic therapies, broad-spectrum antibiotics and immunomodulatory agents. The presentation of the infection includes varying degrees of pain, inflammation and visual loss.

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The clinical examination shows the presence of an anterior segment inflammation, vitreous opacification, choroidoretinal infiltrates, retinal haemorrhages, cotton-wool spots and retinal vasculitis. The progression of the infection depends on the causative organism. With a bacterial infection, rapid progression is expected, fungal infections progress slowly and the speed of viral progression can vary.

Diagnosis of endophthalmitis

Dr Amoaku warned about the “fair degree” of misdiagnosis, which is as high as about 63%. “A high degree of suspicion for endophthalmitis is needed to establish the diagnosis,” he cautioned. He also noted the importance of ruling out intraocular lymphoma, which mimics endogenous endophthalmitis.

Dr Amoaku cited a 2018 report of the British Ophthalmological Surveillance Unit1 that included 48 patients (median age 56.9 years) from December 2013 to December 2014. About 46% of patients were older than 60, the oldest being 85.

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The presenting features in these patients included cellulitis; afferent pupillary defect; corneal clarity; anterior chamber cells; hypopyon; fibrin; vitritis; retinitis; and others, which were similar to those reported in the literature. “Typically, in these patients the endophthalmitis was unilateral and included bacterial, viral and fungal infections,” he said.

Upon presentation, the vision was already poor, with a median of 3 logarithms of the minimum angle of resolution visual acuity (logMAR VA). Several infection sources identified in addition to the strong association with diabetes included septic arthritis, colon cancer, cardiac valve disease and intravenous drug use.

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The blood cultures were positive in 58% of patients; in contrast, vitreous biopsies were positive in only about 23%. The causative organism was more likely to be identified in patients who presented early after the onset of symptoms. Treatment included a combination of systemic intravenous or oral antibiotics, intravitreal antibiotics, antifungal drugs and mostly topical corticosteroids.

A total of 25 patients, including one who died, were followed for 6 months. The median visual acuity (VA) was 0.18 logMAR; the VA was below one in four of 23 patients and below 0.3 in 19 patients. Poor outcomes were characterised by no light perception and light perception VA.

UK treatment recommendations: systemic and ocular

“A full systemic work-up is necessary to determine the source of the infection and a high degree of suspicion is required,” Dr Amoaku said. “The mandatory examinations include ophthalmic ultrasound and intraocular biopsy of the vitreous for microscopy, culturing and sensitivity and blood cultures. Cardiac echography, abdominal ultrasound and MRI are indicated as appropriate.” Importantly, Dr Amoaku noted that diabetes must be excluded in all cases.

The intraocular treatment begins based on the clinical features and presumed diagnosis. After the vitreous biopsy results are received, treatment is modified as needed. Intravitreal therapy includes vancomycin 1 mg/0.1 ml plus amikacin 0.4 mg/0.1 ml or ceftazidime 1 mg/0.1 ml for bacterial infections and amphotericin B for fungal infections. Ganciclovir is prescribed for viral infections.

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At 3–5 days after the initial treatment, the treatment is repeated depending on the diagnosis and the response. Vitrectomy is reserved to treat a few selected cases.

Dr Amoaku emphasised that the systemic anti-infective treatment specific to the infectious agent is mandatory for all cases. When the infection is under control, systemic corticosteroids can be started.

Reference
Maling S, King C, Davies N. A British Ophthalmological Surveillance Unit study on metastatic endogenous endophthalmitis. Eye (Lond). 2018;32:743-748.
Winfried M. K. Amoaku, PhD, MBChB, FRCS
e: wma@nottingham.ac.uk
This article is adapted from Dr Amoaku’s presentation at the American Academy of Ophthalmology’s 2020 virtual annual meeting. Dr Amoaku has no financial interest in this subject matter.

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