Articles

The Verteporfin Intravitreal Triamcinolone Acetonide Study (VERITAS) of intravitreal triamcinolone acetonide (Kenalog, Bristol-Myers Squibb) or pegaptanib (Macugen, Pfizer) in combination with photodynamic therapy (PDT) with verteporfin (Visudyne, Novartis Pharmaceuticals) was underpowered to reach definitive conclusions about the therapies.

The higher level of advanced glycation end products (AGE) in senile diabetic patients may correlate to a higher rate of cataract development, according to a study published in the May?June 2008 issue of the Journal of Diabetes and its Complications.

Further study is needed to establish the role of multifocal IOLs in eyes with glaucomatous damage, according to Ike Ahmed, MD, who was speaking during the glaucoma subspecialty day at the annual meeting of the American Society of Cataract and Refractive Surgery.

Following positive clinical trial results, Allergan, the makers of bimatoprost, are submitting a new drug application (NDA) to the US Food and Drug Administration (FDA), seeking a new indication for the prostaglandin analogue as an eyelash growth stimulant.

Diabetic retinopathy (DR) is an independent risk factor for heart failure (HF), according to a study published in the April 22 2008 issue of the Journal of the American College of Cardiology.

Absence of a specific RNase III endonuclease in the retina causes no immediate structural abnormalities but does prompt total retinal inactivity, according to a study published in the May 7 2008 issue of the Journal of Neuroscience.

Eric Greve, one of the founding members of the European Glaucoma Society (EGS), has been honoured during a lunchtime ceremony at its quadrennial International Congress, held June 1–6 in Berlin, Germany.

Although fluorescein angiography (FA) and optical coherence tomography (OCT) are both effective ways to detect macular oedema (ME), when used in isolation they may miss subtle manifestations of the condition, according to a study published in the April 2008 issue of Retina.

Ganfort beats Xalacom

A bimatoprost and timolol fixed combination (Ganfort; Allergan) is more effective at lowering intraocular pressure (IOP) over 12 weeks than latanoprost (Xalacom; Pfizer), according to results presented at the meeting of the European Glaucoma Society (EGS), held June 1–6 in Berlin.

Intravitreal injections of bevacizumab (Avastin; Genentech) stabilize vision and decrease retinal detachment in patients with polypoidal choroidal vasculopathy (PCV), according to a study published in the May 2008 issue of the British Journal of Ophthalmology.

The European Glaucoma Society (EGS) has officially unveiled the updated edition of its "Terminology and Guidelines for Glaucoma" at its 8th International Congress, held June 1?6 in Berlin.

Depression in retinitis pigmentosa (RP) patients worsens vision-related function even where visual acuity is not compromised, according to a study published in the May 2008 issue of the British Journal of Ophthalmology.

US firm Acucela Inc. has dosed the first patient in the Phase I trial of its lead candidate, ACU-02, an oral compound which is in development for dry age-related macular degeneration (AMD).

Bevasiranib, a small interfering RNA (siRNA) compound targeting vascular endothelial growth factor-A (VEGF-A), is distributed throughout the eye, including the retina, according to a study published on 28 May 2008 in Molecular Vision.

Santen Pharmaceutical Co. Ltd. (Japan) and MacuSight Inc. (US) are to collaborate on developing MacuSight's sirolimus to treat ocular conditions including diabetic macular oedema (DME) and wet age-related macular degeneration (AMD).

The truth about LASIK

After hearing a variety of testimonies to discuss the post-market experience of LASIK, advisers to the FDA determined that lasers need improved patient labeling information. The advisers determined that the LASIK procedure itself is not the culprit; rather, it may be poor screening of possible candidates and misconstrued or insufficient information about the procedure relayed to patients. Ophthalmologists said that LASIK has a very high patient satisfaction rate and enumerated considerations for approaching studies of patient dissatisfaction.

Bausch & Lomb (B&L) bought by Warburg Pincus last October has a long-term growth plan and will not return to the public market any time soon, said Gerry Ostrov, chief executive officer, B&L.

Azarga (brinzolamide 1%/timolol 0.5% eye drops suspension; Alcon) and Cosopt (dorzolamide 2%/timolol 0.5% eye drops solution; Merck) are equally efficacious in IOP-lowering capacity, however, Azarga offers greater ocular comfort, according to a study presented at this week?s European Glaucoma Society congress in Berlin, Germany.

The diuretic agents, vasopressin-receptor antagonists, or vaptans, may have a use in the treatment of glaucoma, according to a study appearing in the 10 May, 2008 issue of The Lancet.

Avastin (bevacizumab) does not exert any toxic effects on the retina and its function, according to a study published in the January issue of Retina journal.

Delaying treatment in patients with subfoveal neovascular age-related macular degeneration (wet AMD) correlates to progressive and substantial loss of visual acuity (VA), according to a report published online ahead of print by Eye.

The OPTTX System (Novadaq Technologies) stabilizes or improves vision at one year in patients with wet age-related macular degeneration (AMD), many of who have failed previous therapies and have no other treatment alternatives, according to Professor Giovanni Staurenghi of Sacco Hospital, University of Milan, Italy, reporting at this year?s EURETINA congress in Vienna, Austria.

Anaesthesia administered by sharp needles carries a greater risk of serious complications than subtenons cannula administration, according to a study published online ahead of print in Eye.

Posterior keratocyte density measurements could be a means of following eyes with post-LASIK ectasia, according to study results presented at this year's meeting of the American Academy of Ophthalmology (AAO).

The month in which one is born may increase the likelihood of suffering severe myopia, according to a study published in the April 2008 issue of Ophthalmology.

It is widely accepted, anecdotally, that long-term exposure to television and computer screens causes a reaction in the eyes; namely, blurred vision, redness and dry eye symptoms. But is this a condition that is worthy of its own name?