Vitrectomy drug alternative continues to impress

Article

The Phase IIb trial assessing the safety and efficacy of microplasmin in patients, showed complete resolution of vitreomacular traction or macular hole without need for vitrectomy surgery, according to a statement from the trial sponsor, ThromboGenics NV.

The Phase IIb trial assessing the safety and efficacy of microplasmin in patients, showed complete resolution of vitreomacular traction or macular hole without need for vitrectomy surgery, according to a statement from the trial sponsor, ThromboGenics NV.

Dr Kirk Packo, Professor and Chairman at the Department of Ophthalmology, Rush University Medical Center in Chicago, US presented the six-month results of the randomized, double-masked, multicentre, dose-evaluation study at the meeting of the American Academy of Ophthalmology (AAO).

The results, consistent with the one-month follow-up data presented at the World Ophthalmology Congress in Hong Kong, demonstrated that a 125µg intravitreal dose of microplasmin treated the condition successfully, so that the need for vitrectomy was bypassed, in approximately one third of cases. Those patients who had achieved disease resolution at one month maintained this improvement at six months. At this time point, visual acuity in patients treated successfully with microplasmin was equal to that of patients who had undergone vitrectomy.

The Phase III trial programme, assessing microplasmin as a treatment for vitreomacular adhesion, is now being finalized. The trial will begin early next year.

Newsletter

Get the essential updates shaping the future of pharma manufacturing and compliance—subscribe today to Pharmaceutical Technology and never miss a breakthrough.

Recent Videos
Omer Trivizki, MD, MBA, a retina specialist from Tel Aviv Medical Center, speaks about VOY-101, a Novel, Complement-Modulating Gene Therapy for Geographic Atrophy at the American Society of Retina Specialists (ASRS) Annual Meeting
João Pedro Marques, MD, MSc, PhD discusses a retrospective study of 800 patients with inherited retinal diseases during the American Society of Retina Specialists (ASRS) annual meeting
Christine Curcio, PhD, of the University of Alabama at Birmingham Heersink School of Medicine, shares histology update and revised nomenclature for OCT with Sheryl Stevenson of the Eye Care Network and Ophthalmology Times
© 2025 MJH Life Sciences

All rights reserved.