Visgenx issued US patent for compositions of ELOVL2 gene therapy


The patent is also being prosecuted in the European Union and around the globe

A photo of a US patent application. Image credit: ©Golib Tolibov –

Visgenx executives praised the patent for adding value to its dry age-related macular degeneration programme. Image credit: ©Golib Tolibov –

Visgenx Inc announced that the United States Patent and Trademark Office has issued US Patent No. 11,793,890, titled “ELOVL2 Constructs for Human Gene Therapy”. According to a news release,1 the patent, which is exclusively owned by Visgenx, has an expiration date of October 19, 2041. The company also announced that the patent is being prosecuted in the EU, as well as other countries around the world.

Marty Emanuele, PhD, co-founder and chief science officer at Visgenx, noted in the news release the gene is key because its expression is believed to be necessary for the survival of cells in the retina and other organ systems.1

"However, it is also uniquely susceptible to aging related methylation of its promotor and down regulation,” Emanuele said in the news release. “Thus, decline in its expression may play an underlying role in multiple aging related disorders including age-related macular degeneration. Accordingly, we believe that ELOVL2 gene therapy is an attractive strategy for treating these conditions."

Chris Chavez, PhD, vice president of Research and Development at Visgenx and primary inventor on the patent, noted it covers an optimised ELOVL2 transgene that can be used in expression vectors targeting multiple tissues.1

"We believe the issued patent adds substantial value not only to our lead programme in dry AMD, but also provides the basis for a platform of ELOVL2 based therapeutics to treat aging related disorders in other tissues where it is highly expressed including the brain, liver and pancreas,” he said.

In June 2023, Visgenx unveiled positive data from a non-human primate study.2

The translational study used a single subretinal injection to deliver VGX-0111 (carrying an ELOVL2 transgene) to investigate whether VGX-0111 expresses in the target tissues and causes an increase in certain very long chain polyunsaturated fatty acids at a dose that is well tolerated, according to a news release. The company noted VGX-0111 was able to successfully demonstrate all three of these important parameters.2

The company noted in its news release in June the ELOVL2 enzyme plays a key role in the biosynthesis of LC and VLC PUFAs. During aging, expression of the ELOVL2 gene declines, resulting in a drop in the LC and VLC PUFAs needed for vision.

Moreover, the company noted VGX-0111 is an experimental gene therapy intended to increase expression of ELOVL2. It is thought that restoring physiological ELOVL2 expression will increase levels of LC and VLC PUFAs in the retina and slow or halt the progression of dry AMD.2

"The findings demonstrate that it is possible to increase the fatty acids whose decline is associated with dry AMD with a well-tolerated treatment in a species closely related to humans,” Emanuele said in a news release at the time. “This is very encouraging and bodes well for further development."


1. Visgenx Announces Issuance of a U.S. Patent Claiming Compositions of Candidate ELOVL2 Gene Therapy. Biospace. Accessed October 25, 2023.

2. Visgenx. Visgenx Announces Positive Results from a Key Translational Study for its Gene Therapy Candidate for Dry AMD. PRNewswire.

Related Videos
ARVO 2024: Andrew D. Pucker, OD, PhD on measuring meibomian gland morphology with increased accuracy
 Allen Ho, MD, presented a paper on the 12 month results of a mutation agnostic optogenetic programme for patients with severe vision loss from retinitis pigmentosa
Noel Brennan, MScOptom, PhD, a clinical research fellow at Johnson and Johnson
ARVO 2024: President-elect SriniVas Sadda, MD, speaks with David Hutton of Ophthalmology Times
Elias Kahan, MD, a clinical research fellow and incoming PGY1 resident at NYU
Neda Gioia, OD, sat down to discuss a poster from this year's ARVO meeting held in Seattle, Washington
Eric Donnenfeld, MD, a corneal, cataract and refractive surgeon at Ophthalmic Consultants of Connecticut, discusses his ARVO presentation with Ophthalmology Times
John D Sheppard, MD, MSc, FACs, speaks with David Hutton of Ophthalmology Times
Paul Kayne, PhD, on assessing melanocortin receptors in the ocular space
Osamah Saeedi, MD, MS, at ARVO 2024
© 2024 MJH Life Sciences

All rights reserved.