Trypan blue deemed safe in vireoretinal surgery

Article

According to data recently published, trypan blue (TB) doesn't cause injury to the retinal pigment epithelium (RPE) when used in vitreoretinal surgery...

According to data recently published in the Journal Retina, trypan blue (TB) doesn't cause injury to the retinal pigment epithelium (RPE) when used in vitreoretinal surgery.

Dr Ehab Abdelkader et al. from the Grampian University Hospitals-NHS Trust, Aberdeen, UK, examined the in vivo safety of TB in patients treated with TB-assisted internal limiting membrane or epiretinal membrane peeling. The study group comprised 21 eyes of 21 patients that had full-thickness macular hole and/or epiretinal membrane. Distance and near visual acuity (VA) were measured along with amplitude of P50 and N95 of the pattern electroretinogram and fundus autofluorescence preoperatively and 6 and 12 months postoperatively.

The researchers found that there was a statistically significant improvement in distance and near VA as well as P50 and N95 amplitude at both post-op follow-ups. Additionally, autofluorescence analysis proved that there was no damage to the RPE as a result of TB.

Based on the results it was concluded that TB does not cause harmful effects in vitreoretinal surgery.

Newsletter

Get the essential updates shaping the future of pharma manufacturing and compliance—subscribe today to Pharmaceutical Technology and never miss a breakthrough.

Recent Videos
Andreas Pollreisz, MD, discusses widefield OCT-A and fluorescence angiography at the 2025 European Society of Retina Specialists EURETINA meeting
Harvey Uy, MD, DPBO, FVRSP, speaks about artificial intelligence (AI) and optical coherence tomography (OCT) at the 2025 European Society of Retina Specialists (EURETINA) Congress.
EURETINA 2025: Boris Stanzel, MD, methotrexate is rocking the European retina landscape
© 2025 MJH Life Sciences

All rights reserved.