Reversal of retinal ganglion cell dysfunction happens after IOP reduction

Article

A study has shown that the surgical reduction of IOP causes the reversal of retinal ganglion cell (RGC) dysfunction.

A study has shown that the surgical reduction of IOP causes the reversal of retinal ganglion cell (RGC) dysfunction. It was also found that the pattern electroretinogram optimized for glaucoma screening (PERGLA) can be a non-invasive technique to measure RGC function.

Mitra Sehi, Research Assistant Professor of Ophthalmology at Bascom Palmer Eye Institute, University of Miami, USA, conducted a prospective cohort study of 47 eyes of 47 patients with uncontrolled IOP. The patients underwent a total ocular examination, arterial blood pressure, standard automated perimetry (SAP) and PERGLA before surgery and three months after surgery.

The results indicated that mean postoperative IOP was significantly reduced compared with preoperative IOP. PERGLA amplitude after surgery increased compared to preoperative PERGLA amplitude. Thirty-four of the 47 eyes underwent trabeculectomy with antifibrosis therapy, 13 eyes had glaucoma drainage implant surgery.

The conclusion was that the reversal of RGC dysfunction happens after surgical reduction of IOP and can be measured using PERGLA.

Newsletter

Join ophthalmologists across Europe—sign up for exclusive updates and innovations in surgical techniques and clinical care.

Recent Videos
Christine Curcio, PhD, of the University of Alabama at Birmingham Heersink School of Medicine, shares histology update and revised nomenclature for OCT with Sheryl Stevenson of the Eye Care Network and Ophthalmology Times
SriniVas R. Sadda, MD, FARVO, shares key points from his retina presentation at the International SPECTRALIS Symposium
Robert Sergott, MD, describes fluorescence lifetime imaging ophthalmoscopy (FLIO) and the International SPECTRALIS Symposium – And Beyond (ISS) in Heidelberg, Germany.
Rayaz Malik, MBChB, PhD, a professor of medicine at Weill Cornell Medicine - Qatar, spoke with Ophthalmology Times Europe about his presentation. It's titled "An eye on neurodegenerative diseases: Challenging the dogma" at the International SPECTRALIS Sympsoium. In conversation with Hattie Hayes, Ophthalmology Times Europe
Anat Loewenstein, MD, describes her presentation on remote imaging for age-related macular degeneration and geographic atrophy at the International SPECTRALIS Symposium, in conversation with Hattie Hayes of Ophthalmology Times Europe
Tyson Brunstetter, OD, PhD, a US Navy Aerospace Optometrist at the NASA Johnson Space Center in Houston, Texas, shares key takeaways from his keynote at the International SPECTRALIS Symposium (ISS)
Rayaz Malik, MBChB, PhD, shares his presentation, titled An eye on neurodegenerative diseases: Challenging the dogma, at this year's International SPECTRALIS Symposium
At the Retina World Congress, Siegfried Priglinger, MD, speaks about ensuring the best outcomes for preschool-aged patients
At the 2025 ASCRS meeting, Robert Ang, MD said small aperture IOLs can benefit all patients, especially those with complex corneas or who have undergone previous corneal refractive surgery
Viha Vig, MBChB graduate student at the University of Auckland, New Zealand, discusses her poster presentation on the relationship between mitochondiral disease, Alzheimer disease, and other types of dementia.
© 2025 MJH Life Sciences

All rights reserved.