Regrowth of optic nerve cells achieved

Article

It may be possible to regenerate optic neural axons by manipulating growth control pathways, according to study results published in the 7 November issue of the journal Science.

It may be possible to regenerate optic neural axons by manipulating growth control pathways, according to study results published in the 7 November issue of the journal Science.

Zhigang He, PhD, BM of the Children's Hospital, Boston, US and colleagues removed a single regulator from retinal ganglion cells (RGCs) of wild-type adult mice in vivo. The receptor, phosphatase and tensin homolog (PTEN), is implicated in the mammalian target of rapamycin (mTOR) pathway.

The team found that removing PTEN was associated with inhibition of mTOR activity and protein synthesis, which prevented axon regeneration. When the mTOR pathway was reactivated by a different regulator, axon regeneration was resumed.

The researchers therefore concluded that modulating growth control pathways could potentially encourage axon regeneration, offering a possible therapeutic solution to optic nerve damage.

Newsletter

Get the essential updates shaping the future of pharma manufacturing and compliance—subscribe today to Pharmaceutical Technology and never miss a breakthrough.

Recent Videos
Jay Chhablani, MD, shares late-breaking data from the ArMaDa trial, investigating gene therapy for Geographic Atrophy and dry age-related macular degeneration, at EURETINA
Editorial advisory board member Alexandra Miere, MD, PhD, speaks about the ACTOR and HERMES studies at the 2025 European Society of Retina Specialists (EURETINA) Congress
María Berrocal, MD, speaks about the Vit-Buckle Society symposium hosted at the 2025 European Society of Retina Specialists (EURETINA) annual meeting
© 2025 MJH Life Sciences

All rights reserved.