Paediatric retinal dysfunction linked to high vigabatrin doses

February 2, 2012

Paediatric retinal dysfunction may be linked to exposure to high daily doses of vigabatrin.

Paediatric retinal dysfunction may be linked to exposure to high daily doses of vigabatrin, reveals a study in the Journal of Paediatric Ophthalmology and Strabismus.

Dr Ulrika Kjellstrom and her team, Department of Ophthalmology, University of Lund, Sweden, investigated the full-field electroretinographies (ff-ERG) of 14 children who were administered vigabatrin.

Drug dosage parameters were compared in all participants, along with the ff-ERGs from healthy controls and were grouped according to age.

For the isolated rod response, combined rod-cone response and the 30 Hz flicker response there was reduced b-wave amplitudes. In 57% of the children who received vigabatrin there were significant changes in ff-ERG. The study showed no differences in cumulative doses or duration of medication.

The study suggests that careful follow-up should be performed for children who are administered vigabatrin, as high doses are linked to retinal dysfunction and photoreceptor damage.