Non-surgical periocular nodular-BCC treatments are successful

Article

Imiquimod (IMQ) 5% cream and radiotherapy (RT) are both effective for treating periocular nodular-based cell carcinoma (BCC)

Imiquimod (IMQ) 5% cream and radiotherapy (RT) are both effective for treating periocular nodular-based cell carcinoma (BCC), according to a study published in the British Journal of Ophthalmology.

Dr Elena Garcia-Martin et al., Hospital Universitario Miguel Servet, Zaragoza, Spain, examined 27 patients with clinical and histopathological diagnosis of nodular BCC on the eyelid. IMQ 5% cream was administered in 15 patients once daily 5 days a week for 6 weeks. RT was performed in 12 patients.

Within 3 months of treatment all patients demonstrated histopathological remission. Sustained clinical remission was recorded in every patient after 24 months follow-up. Toleration of treatment for IMQ and RT was recorded as moderate and good, respectively.

The investigation concluded that the non-surgical methods of using IMQ and RT were successful in treating eyelid nodular BCCs. IMQ demonstrated better cosmesis and functional results, whereas RT demonstrated a better tolerability.

Newsletter

Join ophthalmologists across Europe—sign up for exclusive updates and innovations in surgical techniques and clinical care.

Recent Videos
Alfredo Sadun, MD, PhD, chief of Ophthalmology at the Doheny Eye Institute, University of California Los Angeles, shared exciting new research with the Eye Care Network during the Association for Research in Vision and Ophthalmology (ARVO) meeting on the subject of Leber hereditary optic neuropathy (LHON).
At this year's Association for Research in Vision and Ophthalmology (ARVO) meeting in Salt Lake City, Utah, Nitish Mehta, MD, shared highlights from his research documenting real-world results of aflibercept 8 mg for patients with diabetic macular oedema.
ARVO 2025: Anat Loewenstein, MD, shares data from herself and her colleagues on meeting needs of patients with diabetic retinopathy
At the American Society of Cataract and Refractive Surgeons annual meeting, Sheng Lim, MD, FRCOphth discusses the benefit of endoscopic cyclophotocoagulation for patients with primary open angle glaucoma and cataracts in the CONCEPT study
A photo of Seville, Spain, with the Congress on Controversies in Ophthalmology logo superimposed on it. Image credit: ©francovolpato – stock.adobe.com; logo courtesy COPHy
Anat Loewenstein, MD, Professor and Director, Department of Ophthalmology, Tel Aviv Medical Center, discusses the Congress on Controversies in Ophthalmology (COPHy)
Anat Loewenstein, MD, speaks about the 22nd Annual Angiogenesis, Exudation, and Degeneration Meeting in February 2025 and shares her global forecast for AI-driven home OCT
Sarah M. Thomasy, DVM, PhD, DACVO, a veterinary ophthalmologist at UC Davis, talks about how her research at the Glaucoma 360 symposium
I. Paul Singh, MD, an anterior segment and glaucoma specialist, discusses the Glaucoma 360 conference, where he participated in a panel discussion on the use of artificial intelligence (AI) in glaucoma care.
Charles Wykoff, MD, PhD, discusses his Floretina ICOOR presentation topic, retinal non-perfusion in diabetic retinopathy, with David Hutton, editor of Ophthalmology Times
© 2025 MJH Life Sciences

All rights reserved.