NicOx reacquires rights to PF-03187207 for glaucoma from Pfizer

August 19, 2009

NicOx S.A. has signed an agreement with Pfizer Inc to reacquire the full development and commercialization rights to PF-03187207, which has completed two phase II studies in patients with primary open angle glaucoma and ocular hypertension. As part of this agreement, Pfizer has granted NicOx the right to access and use certain proprietary Xalatan (latanoprost) data.

NicOx S.A. has signed an agreement with Pfizer Inc to reacquire the full development and commercialization rights to PF-03187207, which has completed two phase II studies in patients with primary open angle glaucoma and ocular hypertension. As part of this agreement, Pfizer has granted NicOx the right to access and use certain proprietary Xalatan (latanoprost) data.

Under the new agreement and following Pfizer's announced strategic review process, NicOx is also regaining rights to a number of novel, research- stage, nitric oxide-donating compounds for the potential treatment of diabetic retinopathy and glaucoma. The compounds targeting diabetic retinopathy have produced positive results in a variety of models showing their potential benefit for the treatment of this prevalent eye disease, for which existing treatments are inadequate. The agreement announced today supersedes and concludes NicOx' previous August 2004 and March 2006 agreements with Pfizer and follows the receipt of the last annual research funding of EUR 3 million by NicOx in March 2008.