New AMD drug enters trials

Article

iSONEP (sonepcizumab), Lpath, Inc's drug candidate for treating age-related macular degeneration (AMD), has been administered to the first patients in its Phase I trial.

iSONEP (sonepcizumab), Lpath, Inc.'s drug candidate for treating age-related macular degeneration (AMD), has been administered to the first patients in its Phase I trial.

Unlike other AMD treatments, iSONEP, an antibody, targets not vascular endothelial growth factor (VEGF) but sphingosine-1-phosphate (S1P), a bioactive lipid that promotes angiogenesis, inflammation, cell survival and cell proliferation.

Lpath believes that, unlike anti-VEGF drugs, a treatment targeting the S1P pathway would arrest disease progression by reducing inflammation and mitigating fibrosis in addition to its anti-angiogenic properties. Although this hypothesis has been validated in animal trials, there are currently no S1P antibody therapies available for human use.

Lpath hopes that iSONEP will prove a viable candidate, either alone or as an adjunct to anti-VEGF treatments, for AMD as well as potentially having application in other fibrosis, angiogenesis or inflammation disorders.

Recent Videos
John T. Thompson, MD, discusses his presentation at ASRS, Long-Term Results of Macular Hole Surgery With Long-Acting Gas Tamponade and Internal Limiting Membrane Peeling
ASRS 2024: Michael Singer, MD, shares 100-week results from the RESTORE trial
Paulo Antonio Silva, Associate Professor of Ophthalmology at Harvard Medical School
Intraocular Pressure Outcomes Following Suprachoroidal Triamcinolone Acetonide in Patients With Glaucoma, Ocular Hypertension, or Steroid Response
Durga Borkar, MD, MMCi, discusses FAS inhibition with ONL-1204
Theodore Leng, MD, MS, speaks about 12-Month Real-World Clinical and Anatomical Outcomes With Faricimab in Patients With Diabetic Macular Edema:The FARETINA-DME Study
Rishi P. Singh, MD, discussed his presentation on the results from part 1 of the Phase 2/3 SIGLEC trial assessing AVD-104 for GA
Carl C. Awh, MD, FASRS, speaks with Hattie Hayes of Ophthalmology Times Europe
© 2024 MJH Life Sciences

All rights reserved.