Long-term use of intravitreous bevacizumab treats CSME

Article

The long-term use of intravitreous bevacizumab can be used to treat patients with persistant clinically significant macula oedema (CSME).

The long-term use of intravitreous bevacizumab can be used to treat patients with persistant clinically significant macula oedema (CSME), claims a study in the Archives of Ophthalmology.

Dr Ranjan Rajendram et al., Department of Medical Retina, Moorfields Eye Hospital, London, UK, conducted a two year single-centred, randomized, controlled trial on 80 CSME patients. Each participant was randomized to receive either bevacizumab or macular laser therapy (MLT).

The primary outcome was difference in Early Treatment Diabetic Retinopathy Study (ETDRS) best-corrected visual acuity (BCVA). The secondary outcomes were mean change in best-corrected visual acuity (BCVA), central macula thickness changes, ETDRS retinopathy severity, safety outcomes and the propertion of patients gaining a minimum of 15 and 10 ETDRS letters.

At two years the mean ETDRS BCVA was 64.4 for the bevacizumab group and 54.8 for the MLT group. A median of nine ETDRS letters was gained in the bevacizumab group and 2.5 letters were gained in the MLT group.

In the bevacizumab group 49% gained 10 or more letters and 32% gained 15 letters. In the MLT group 7% and 4% of patients gained 10 and 15 letters, respectively. In the bevacizumab group all patients lost fewer than 15 letters, compared to 86% in the MLT group.

At 146 µm the mean reduction in central macular thickness was considerably higher in the bevacizumab group, compared to 118 µm in the MLT group. The improvements seen in BCVA and central macular thickness were maintained in second year with an average of four injections.

Newsletter

Join ophthalmologists across Europe—sign up for exclusive updates and innovations in surgical techniques and clinical care.

Recent Videos
Christine Curcio, PhD, of the University of Alabama at Birmingham Heersink School of Medicine, shares histology update and revised nomenclature for OCT with Sheryl Stevenson of the Eye Care Network and Ophthalmology Times
SriniVas R. Sadda, MD, FARVO, shares key points from his retina presentation at the International SPECTRALIS Symposium
Robert Sergott, MD, describes fluorescence lifetime imaging ophthalmoscopy (FLIO) and the International SPECTRALIS Symposium – And Beyond (ISS) in Heidelberg, Germany.
Rayaz Malik, MBChB, PhD, a professor of medicine at Weill Cornell Medicine - Qatar, spoke with Ophthalmology Times Europe about his presentation. It's titled "An eye on neurodegenerative diseases: Challenging the dogma" at the International SPECTRALIS Sympsoium. In conversation with Hattie Hayes, Ophthalmology Times Europe
Anat Loewenstein, MD, describes her presentation on remote imaging for age-related macular degeneration and geographic atrophy at the International SPECTRALIS Symposium, in conversation with Hattie Hayes of Ophthalmology Times Europe
Tyson Brunstetter, OD, PhD, a US Navy Aerospace Optometrist at the NASA Johnson Space Center in Houston, Texas, shares key takeaways from his keynote at the International SPECTRALIS Symposium (ISS)
Rayaz Malik, MBChB, PhD, shares his presentation, titled An eye on neurodegenerative diseases: Challenging the dogma, at this year's International SPECTRALIS Symposium
At the Retina World Congress, Siegfried Priglinger, MD, speaks about ensuring the best outcomes for preschool-aged patients
At the 2025 ASCRS meeting, Robert Ang, MD said small aperture IOLs can benefit all patients, especially those with complex corneas or who have undergone previous corneal refractive surgery
Viha Vig, MBChB graduate student at the University of Auckland, New Zealand, discusses her poster presentation on the relationship between mitochondiral disease, Alzheimer disease, and other types of dementia.
© 2025 MJH Life Sciences

All rights reserved.