Levofloxacin more effective than vancomycin

Article

Levofloxacin is a viable treatment for endophthalmitis, according to a study published online ahead of print by the British Journal of Ophthalmology.

Levofloxacin is a viable treatment for endophthalmitis, according to a study published online ahead of print by the British Journal of Ophthalmology.

Consuelo Ferrer, PhD of the Vissim Institute of Ophthalmology, Alicante, Spain and colleagues compared intravitreal 1.5% levofloxacin monotherapy with 1% vancomycin plus 2.2% ceftazidime combination therapy against bacterial endophthalmitis in 75 New Zealand White rabbit eyes.

The eyes were injected with Staphylococcus epidermidis, Staphylococcus aureus or Pseudomonas aeruginosa and then treated with one of the two therapy options, or control. Vitreous and aqueous humour samples were harvested 24 hours after treatment, and colony-forming units (CFU) per millilitre of each sample was tested at day two, three, five and eight.

No statistically significant difference in CFU/ml between the levofloxacin and the combination treatment was seen in the vitreous humour of any of the eyes. In aqueous humour of the S. epidermidis eyes, levofloxacin monotherapy produced a 3 log decrease in CFU/ml over control; combination therapy produced a 5 log decrease in CFU/ml over control. In aqueous humour of the S. aureus eyes, levofloxacin monotherapy produced a 4 log decrease in CFU/ml over control; combination therapy produced a 2 log decrease in CFU/ml over control. In aqueous humour of the P. aeruginosa eyes, levofloxacin monotherapy produced a 5 log decrease in CFU/ml over control; combination therapy produced a 3–4 log decrease in CFU/ml over control.

The researchers concluded that levofloxacin is effective in the treatment of endophthalmitis in an experimental model although it must be tested further before it can be used in a clinical setting.

Newsletter

Join ophthalmologists across Europe—sign up for exclusive updates and innovations in surgical techniques and clinical care.

Recent Videos
Alfredo Sadun, MD, PhD, chief of Ophthalmology at the Doheny Eye Institute, University of California Los Angeles, shared exciting new research with the Eye Care Network during the Association for Research in Vision and Ophthalmology (ARVO) meeting on the subject of Leber hereditary optic neuropathy (LHON).
At this year's Association for Research in Vision and Ophthalmology (ARVO) meeting in Salt Lake City, Utah, Nitish Mehta, MD, shared highlights from his research documenting real-world results of aflibercept 8 mg for patients with diabetic macular oedema.
ARVO 2025: Anat Loewenstein, MD, shares data from herself and her colleagues on meeting needs of patients with diabetic retinopathy
At the American Society of Cataract and Refractive Surgeons annual meeting, Sheng Lim, MD, FRCOphth discusses the benefit of endoscopic cyclophotocoagulation for patients with primary open angle glaucoma and cataracts in the CONCEPT study
A photo of Seville, Spain, with the Congress on Controversies in Ophthalmology logo superimposed on it. Image credit: ©francovolpato – stock.adobe.com; logo courtesy COPHy
Anat Loewenstein, MD, Professor and Director, Department of Ophthalmology, Tel Aviv Medical Center, discusses the Congress on Controversies in Ophthalmology (COPHy)
Anat Loewenstein, MD, speaks about the 22nd Annual Angiogenesis, Exudation, and Degeneration Meeting in February 2025 and shares her global forecast for AI-driven home OCT
Sarah M. Thomasy, DVM, PhD, DACVO, a veterinary ophthalmologist at UC Davis, talks about how her research at the Glaucoma 360 symposium
I. Paul Singh, MD, an anterior segment and glaucoma specialist, discusses the Glaucoma 360 conference, where he participated in a panel discussion on the use of artificial intelligence (AI) in glaucoma care.
Charles Wykoff, MD, PhD, discusses his Floretina ICOOR presentation topic, retinal non-perfusion in diabetic retinopathy, with David Hutton, editor of Ophthalmology Times
© 2025 MJH Life Sciences

All rights reserved.