Lenses linked to increased inflammatory markers

Article

Tear levels of inflammatory markers increase in patients who wear corneal refractive therapy lenses, compared to those who wore silicone-hydrogel lenses or no lenses.

Tear levels of inflammatory markers increase in patients who wear corneal refractive therapy lenses, compared to those who wore silicone-hydrogel lenses or no lenses.

A team led by Dr Javier González-Pérez, Ocular Surface and Contact Lens Research Laboratory, Faculty of Optics and Optometry, University of Santiago de Compostela, Spain, compared 60 participants in a prospective, case-controlled study.

Of the subjects studied, 28 wore a silicone-hydrogel lens continuously for 30 nights and 32 wore a corneal refractive therapy lens on an overnight basis. There were also 32 control subjects included in the investigation.

Twelve months after initial lens fitting tear samples were obtained and assayed using ELISA cytokines IL-6 andIL-8, matrix metalloproteinase 9 (MMP-9) and epidermal growth factor (EGF).

EGF significantly rose after 12 months for both lenses and IL-6, IL-8 and MMP-9 only increased after corneal refractive therapy. Inflammatory response for corneal refractive therapy patients was linked to the degree of myopia and the presence of corneal staining.

An increased level of MMP-9 and EGF was associated with the presence of corneal-pigmented arch in those who wore corneal refractive therapy lenses.,/p>

The abstract was recently published in the British Journal of Ophthalmology.

Newsletter

Get the essential updates shaping the future of pharma manufacturing and compliance—subscribe today to Pharmaceutical Technology and never miss a breakthrough.

Recent Videos
Jay Chhablani, MD, shares late-breaking data from the ArMaDa trial, investigating gene therapy for Geographic Atrophy and dry age-related macular degeneration, at EURETINA
Editorial advisory board member Alexandra Miere, MD, PhD, speaks about the ACTOR and HERMES studies at the 2025 European Society of Retina Specialists (EURETINA) Congress
María Berrocal, MD, speaks about the Vit-Buckle Society symposium hosted at the 2025 European Society of Retina Specialists (EURETINA) annual meeting
© 2025 MJH Life Sciences

All rights reserved.