LCD characteristics identified

A paper in Retina has announced the identification of the morphologic characteristics of early onset large colloid drusen using SD-OCT.

Dr Benjamin Guigui et al., Creteil University Eye Clinic, Faculte de Medecine Henri Mondor, Creteil, France, performed a complete ophthalmic examination using SD-OCT in 22 eyes of 11 consecutive patients.

Mean visual acuity was 20/25 and the mean patient age was 35 years old at diagnosis. SD-OCT revealed multiple dome-shaped retinal pigment epithelium detachments corresponding to the drusen. The mean height of the drusen was 199 μm and mean width was 419 μm.

Indocyanine green angiography hypofluorescent LCD were bigger and more reflective on SD-OCT. The characteristics of the retina overlying LCD were wavy and thinned overall.

In 73% of the eyes there was prominent diffuse hyperreflective haze in the Henle fibre layer over drusen. There were no cases of geographic atrophy or choroidal neovascularization.

The SD-OCT features provide an insight on the ultrastructure of LCD. Further studies could be planned for the follow-up and histologic evaluation in order to confirm the clinical significance of LCD.

For more information please read the journal abstract.