LCD characteristics identified

Article

A paper in Retina has announced the identification of the morphologic characteristics of early onset large colloid drusen (LCD) using SD-OCT.

A paper in Retina has announced the identification of the morphologic characteristics of early onset large colloid drusen using SD-OCT.

Dr Benjamin Guigui et al., Creteil University Eye Clinic, Faculte de Medecine Henri Mondor, Creteil, France, performed a complete ophthalmic examination using SD-OCT in 22 eyes of 11 consecutive patients.

Mean visual acuity was 20/25 and the mean patient age was 35 years old at diagnosis. SD-OCT revealed multiple dome-shaped retinal pigment epithelium detachments corresponding to the drusen. The mean height of the drusen was 199 μm and mean width was 419 μm.

Indocyanine green angiography hypofluorescent LCD were bigger and more reflective on SD-OCT. The characteristics of the retina overlying LCD were wavy and thinned overall.

In 73% of the eyes there was prominent diffuse hyperreflective haze in the Henle fibre layer over drusen. There were no cases of geographic atrophy or choroidal neovascularization.

The SD-OCT features provide an insight on the ultrastructure of LCD. Further studies could be planned for the follow-up and histologic evaluation in order to confirm the clinical significance of LCD.

For more information please read the journal abstract.

Newsletter

Join ophthalmologists across Europe—sign up for exclusive updates and innovations in surgical techniques and clinical care.

Recent Videos
Alfredo Sadun, MD, PhD, chief of Ophthalmology at the Doheny Eye Institute, University of California Los Angeles, shared exciting new research with the Eye Care Network during the Association for Research in Vision and Ophthalmology (ARVO) meeting on the subject of Leber hereditary optic neuropathy (LHON).
At this year's Association for Research in Vision and Ophthalmology (ARVO) meeting in Salt Lake City, Utah, Nitish Mehta, MD, shared highlights from his research documenting real-world results of aflibercept 8 mg for patients with diabetic macular oedema.
ARVO 2025: Anat Loewenstein, MD, shares data from herself and her colleagues on meeting needs of patients with diabetic retinopathy
At the American Society of Cataract and Refractive Surgeons annual meeting, Sheng Lim, MD, FRCOphth discusses the benefit of endoscopic cyclophotocoagulation for patients with primary open angle glaucoma and cataracts in the CONCEPT study
A photo of Seville, Spain, with the Congress on Controversies in Ophthalmology logo superimposed on it. Image credit: ©francovolpato – stock.adobe.com; logo courtesy COPHy
Anat Loewenstein, MD, Professor and Director, Department of Ophthalmology, Tel Aviv Medical Center, discusses the Congress on Controversies in Ophthalmology (COPHy)
Anat Loewenstein, MD, speaks about the 22nd Annual Angiogenesis, Exudation, and Degeneration Meeting in February 2025 and shares her global forecast for AI-driven home OCT
Sarah M. Thomasy, DVM, PhD, DACVO, a veterinary ophthalmologist at UC Davis, talks about how her research at the Glaucoma 360 symposium
I. Paul Singh, MD, an anterior segment and glaucoma specialist, discusses the Glaucoma 360 conference, where he participated in a panel discussion on the use of artificial intelligence (AI) in glaucoma care.
Charles Wykoff, MD, PhD, discusses his Floretina ICOOR presentation topic, retinal non-perfusion in diabetic retinopathy, with David Hutton, editor of Ophthalmology Times
Related Content
© 2025 MJH Life Sciences

All rights reserved.