Latanoprost punctual plug delivery system is effective in glaucoma treatment

Article

The latanoprost punctual plug delivery system (L-PPDS) is a safe and effective way of administering glaucoma medication, according to ocular company QLT.

The latanoprost punctual plug delivery system (L-PPDS) is a safe and effective way of administering glaucoma medication, according to ocular company QLT.

A phase II trial was conducted on 95 patients and involved the upper and lower puncta for delivery of a daily drug load. The aim was to compare clinical outcomes between latanoprost and daily Xalatan eye drops.

The primary endpoint was the mean change in IOP from baseline at 2 weeks. The secondary endpoints were the mean change in IOP from baseline at 4 weeks and the mean percentage change in IOP from baseline at 2 and 4 weeks.

After 2 weeks of treatment the mean change in IOP was statistically significant at a baseline of -6.2 mmHg. Of the patients studied, 73% presented with an IOP reduction compared to baseline of 5 mmHg or more and 51% demonstrated a reduction of 6 mmHg or more. At 2 weeks the mean change in IOP baseline was statistically significant at -24.3%.

IOP also changed significantly after 4 weeks of L-PPDS. The mean change from baseline was -5.7 mmHg. Out of the patients, 60% showed a reduction of IOP vs baseline of 5 mmHg or higher.

Related Videos
Ramin Tadayoni, MD, speaks with Sheryl Stevenson
Jennifer I. Lim, MD, FARVO, FASRS, Director of Retina Service, University of Illinois at Chicago
Anat Loewenstein, MD, Professor and Director, Department of Ophthalmology, Tel Aviv Medical Center
Carl D. Regillo, MD, FACS, FASRS, Chief of Retina Service, Wills Eye Hospital, Philadelphia, PA
Arshad Khanani, MD, MA FASRS, on a virtual call
Penny A Asbell, MD, FACS speaks at the 2023 AAO meeting
© 2024 MJH Life Sciences

All rights reserved.