Laser stops, may partially reverse AMD

Article

A novel nanosecond laser therapy has stopped the progression of age-related macular degeneration (AMD) and resulted in resolution of drusen and improved visual function in patients with early-stage high-risk AMD.

The idea to use a nanosecond laser-based treatment to impede the progress of age-related macular degeneration (AMD) seems to have been fruitful.

The results of a pilot study of a non-thermal nanosecond laser therapy [Ellex Retinal Regeneration Therapy (Ellex 2RT), Ellex] indicated that of the 14 patients followed for 6 months after treatment, 10 have improved vision in the treated eye, commented Professor Robyn Guymer, who oversees the Macular Research Unit, Centre for Eye Research Australia, University of Melbourne, Royal, Victorian Eye and Ear Hospital, Melbourne, Australia.

The laser treatment, according to the Centre for Eye Research Australia, involves a specially designed novel laser device that delivers a controlled nanosecond dose of laser energy into the eye. The laser was designed in collaboration with Professor John Marshall, PhD, FRCPath, FRCOphth (Hon), at St Thomas' Hospital, London, UK, who has worked for many years to understand the initial determinants of AMD.

Prof. Guymer and colleagues found that the laser therapy eliminated drusen in the treated eye and in doing so, the investigators hope to reverse the degenerative process of AMD and save patients' sight. The difference between this technology and currently available treatments for AMD is that this laser can be applied before patients actually lose vision. With most AMD treatments, the disease is not addressed until it has reached the late stage, when vision cannot be restored.

Twenty patients with bilateral high-risk early AMD were initially enrolled in the study and one eye of each patient was treated with one dose of energy using the laser. The fellow eye served as a control. The laser was applied in one session with 12 subthreshold 400 µm spots placed in a clock-hour distribution 1400 µm from the fovea in one eye, Prof. Guymer explained.

A major advantage of this laser is that no retinal burns develop, which implies minimal damage to the retinal tissue.

"Of great interest, the 10 fellow eyes also improved in either visual function or drusen resolution," Prof. Guymer said.

This improvement was unexpected, she noted. The parameters that showed improvement in the fellow untreated eye were also dark adaptation, flicker, colour thresholds, visual acuity, or drusen resolution.

Clearly, the laser is inducing some long-term systemic effect that is able to affect the contralateral eye, and we are currently working to investigate possible mechanisms that could cause this response, according to Prof. Guymer.

The investigators found that the greatest retinal dysfunction in the 14 patients was in the parafoveal area, where geographic atrophy usually starts, she said.

"In our first 14 patients, this area of greatest dysfunction improved in seven treated eyes and one fellow eye," she added.

Interestingly, the improvements in the retina were not related to the position of the laser spots nor necessarily where the drusen resolved.

According to the investigators, "it is anticipated that [the laser] will address at least one underlying process in AMD, reduced flux across Bruch's membrane. The laser design should enable the positive features of previous laser studies for early AMD to be harnessed without entertaining any of the negative effects such as neovascularization."

Reversing the drivers

Prof. Guymer said that the improvement that was seen in the area of the worst retinal dysfunction suggested that "the treatment may be reversing the drivers of the disease."

"A long-term, formal, randomized clinical trial is needed to determine if [the laser] does reduce the progression to vision loss in AMD, but the early results are very encouraging," Prof. Guymer said.

The investigators hope to treat a total of 50 patients in the 2-year pilot trial. The laser therapy has also shown promise for the treatment of diabetic macular oedema.

Professor Robyn Guymer is a retinal specialist at the Centre for Eye Research Australia, Melbourne, Australia and Deputy Head, Department of Ophthalmology, University of Melbourne, Australia. She can be contacted by E-mail: rhg@unimelb.edu.au

Study support was provded by Ellex research & Development Pty Ltd and the Victoria State Government.

Prof. Guymer has no financial interest in this technology.

Newsletter

Join ophthalmologists across Europe—sign up for exclusive updates and innovations in surgical techniques and clinical care.

Recent Videos
Christine Curcio, PhD, of the University of Alabama at Birmingham Heersink School of Medicine, shares histology update and revised nomenclature for OCT with Sheryl Stevenson of the Eye Care Network and Ophthalmology Times
SriniVas R. Sadda, MD, FARVO, shares key points from his retina presentation at the International SPECTRALIS Symposium
Robert Sergott, MD, describes fluorescence lifetime imaging ophthalmoscopy (FLIO) and the International SPECTRALIS Symposium – And Beyond (ISS) in Heidelberg, Germany.
Anat Loewenstein, MD, describes her presentation on remote imaging for age-related macular degeneration and geographic atrophy at the International SPECTRALIS Symposium, in conversation with Hattie Hayes of Ophthalmology Times Europe
Tyson Brunstetter, OD, PhD, a US Navy Aerospace Optometrist at the NASA Johnson Space Center in Houston, Texas, shares key takeaways from his keynote at the International SPECTRALIS Symposium (ISS)
Viha Vig, MBChB graduate student at the University of Auckland, New Zealand, discusses her poster presentation on the relationship between mitochondiral disease, Alzheimer disease, and other types of dementia.
Alfredo Sadun, MD, PhD, chief of Ophthalmology at the Doheny Eye Institute, University of California Los Angeles, shared exciting new research with the Eye Care Network during the Association for Research in Vision and Ophthalmology (ARVO) meeting on the subject of Leber hereditary optic neuropathy (LHON).
At this year's Association for Research in Vision and Ophthalmology (ARVO) meeting in Salt Lake City, Utah, Nitish Mehta, MD, shared highlights from his research documenting real-world results of aflibercept 8 mg for patients with diabetic macular oedema.
ARVO 2025: Anat Loewenstein, MD, shares data from herself and her colleagues on meeting needs of patients with diabetic retinopathy
A photo of Seville, Spain, with the Congress on Controversies in Ophthalmology logo superimposed on it. Image credit: ©francovolpato – stock.adobe.com; logo courtesy COPHy
© 2025 MJH Life Sciences

All rights reserved.