Lack of eye drop refrigeration a problem

Article

The inadequate refrigeration of chloramphenicol generics in India could be contributing to the evolution of resistant organisms and impacting the quality of Indian-made products available in Europe, according to a study published in the May 2008 issue of the British Journal of Ophthalmology.

The inadequate refrigeration of chloramphenicol generics in India could be contributing to the evolution of resistant organisms and impacting the quality of Indian-made products available in Europe, according to a study published in the May 2008 issue of the British Journal of Ophthalmology.

Jonathan Aboshiha, MD of the Institute of Ophthalmology, University College London, UK and colleagues measured levels of chloramphenicol thermal breakdown product in samples of generic eye drops (n=48) purchased in Delhi and Madras, India. Storage conditions were also noted.

The team found that no samples had been refrigerated prior to purchase and that, consequently, these samples contained high levels of chloramphenicol thermal breakdown product.

As the levels of breakdown product found in the samples were significantly higher than levels permitted under UK quality assurance standards, the researchers concluded that the recent deregulation of OTC purchasing of chloramphenicol eye drops in Europe could lead to complications with product quality.

Newsletter

Get the essential updates shaping the future of pharma manufacturing and compliance—subscribe today to Pharmaceutical Technology and never miss a breakthrough.

Recent Videos
Harvey Uy, MD, DPBO, FVRSP, speaks about artificial intelligence (AI) and optical coherence tomography (OCT) at the 2025 European Society of Retina Specialists (EURETINA) Congress.
EURETINA 2025: Boris Stanzel, MD, methotrexate is rocking the European retina landscape
Jeremiah Tao, MD, FACS, discusses his Egyptian Ophthalmological Society keynote, which focused on risk management and avoiding surgical complications in oculofacial surgery
© 2025 MJH Life Sciences

All rights reserved.