Investigating efficacy of OC-02 to stimulate the trigeminal nerve for the treatment of dry eyes

The study's primary endpoints were to look at increasing Schirmer's scores, as well as eye discomfort score.

Video transcript

The PEARL [phase] 2 study was looking at the compound OC-02 in treating dry eyes. This is a nasal spray that is used twice a day.

Their primary endpoints were to look at increasing Schirmer's, as well as eye discomfort score. By using this nasal spray twice a day, in four randomized groups — so three different concentrations of OC-02 versus placebo — they found that the Schirmer scores were significantly higher in the drug arms, especially the highest drug concentration. And the eye irritation score was also improved most with the highest concentration of the drug.

This molecule is very similar to the OC-01 molecule, which has been FDA approved and marketed. This particular molecule, because of OC-01 being on the market already, is not going to be licensed in the US for marketing.

The take home message is that the use of the cholinergic agonists as a nasal spray to stimulate the trigeminal nerve is a reasonable mechanism to help treat dry eyes. It's novel; it's different than putting eyedrops in your eyes. It may be beneficial for patients who have trouble putting eyedrops in their eyes. A lot of people are used to using nasal sprays for allergies, for example. And so this modality of treatment, as well as a new mechanism, may have extensive benefits for the patients.

Related Videos
Disrupting the glaucoma treatment paradigm with novel femtosecond laser from ViaLase
Trukera Medical rebranding ushers in new era of expansion into cornea market
2-year data in contralateral eye evaluation gives edge to iStent inject over Hydrus stent
Younger patients often require repeat corneal crosslinking, study finds
Investigators report positive visual outcomes one year after monocular implantation of small aperture IOL
Fluid dynamics in wet macular degeneration: How fluid type affects visual acuity
Utilising AAO cornea preferred practice patterns for corneal oedema, opacifications, ectasia and bacterial keratits
Should endocyclophotocoagulation be considered part of MIGS? Mr Ratnarajan delves in
Investigating better indications and outcomes in laser refractive surgery
Investigating the effects of canaloplasty on corneal epithelium
Related Content
© 2023 MJH Life Sciences

All rights reserved.