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> New research from the UK shows that OptiveTM eye drops have a significantly better effect on conjunctival tissues of patients with mild to moderate dry eye compared with Hylocomod (Na-Hyaluronate) eyedrops1, according to a company media statement.
New research from the UK shows that OptiveTM eye drops have a significantly better effect on conjunctival tissues of patients with mild to moderate dry eye compared with Hylocomod (Na-Hyaluronate) eyedrops1, according to a company media statement. Due to the chronic nature of dry eye, tissue recovery could be considered essential to achieving long-term success. The prevalence of people reporting dry eye symptoms is between 5–30% in the population aged 50 years and older.
About the head-to-head studyA broad group of patients with mild to moderate dry eye were randomised to receive either OptiveTM from Allergan or Na-Hyaluronate once daily for one month. Nearly 50 patients were included in this study. Using fluorescein and lissamine green staining, differences in the conjunctival tissue were evaluated as staining is indicative of ocular surface desiccation and damage. At one month, OPTIVETM patients showed significantly less lissamine staining (p=0.002) compared with patients treated with Na-HyaluronateThese results indicate that OptiveTM is significantly superior to Na-Hyaluronate in stimulating conjunctival tissue recoveryCompliance with both eyedrops was similar indicating that the improvements seen in the OptiveTM patient group is likely due to treatment effects
Results from a recent large observational study2 involving more than 5000 patients show that patients switched from Na-Hyaluronate to OptiveTM have improved quality (using TBUT test) and quantity (using Schirmer 1 tests) of tears. In this open label study, 69% of patients experienced improvement in their dry-eye symptoms following the switch from Na-Hyaluronate to OptiveTM and 80% of patients reported greater comfort following the switch to OptiveTM eyedrops.
References1. Guillion M, Maissa C, Ho C. Evaluation of the effects on conjunctival tissuesof Optive eye-drops over one month usage. Contact Lens and Anterior Eye, 33 (2); 2010: 93-992. Kaecher T, Buccholz P, Kimmich F. Clin Ophthalmol 2009; 3: 33-39