Graft rejection therapy enters Phase III

Article

GS-101, Gene Signal's experimental topical ophthalmic solution designed to prevent the rejection of corneal grafts, has entered Phase III trials.

GS-101, Gene Signal's experimental topical ophthalmic solution designed to prevent the rejection of corneal grafts, has entered Phase III trials. The solution, an antisense oligonucleotide, inhibits the expression of insulin-receptor substrate-1 (IRS-1), which is essential for corneal neovascularization.

The results of the multicentre, double-blind, randomized Phase II trial, presented at this year's meeting of the American Academy of Ophthalmology (AAO) by Professor Claus Cursiefen of the department of ophthalmology at Germany's Friedrich Alexander University, demonstrated the safety and efficacy of the solution in suppressing the formation of new blood vessels in the cornea. Over the three month study period, in which 40 patients were treated, corneal neovascularization progressed in 100% of subjects receiving placebo therapy; patients treated with GS-101 twice daily (at doses of 43 µg, 86 µg and 172 µg) achieved up to 86% regression.

In addition to the Phase III trial of GS-101, Gene Signal is developing several other antisense oligonucleotides for the treatment of diseases related to angiogenesis.

Related Videos
Ramin Tadayoni, MD, speaks with Sheryl Stevenson
Jennifer I. Lim, MD, FARVO, FASRS, Director of Retina Service, University of Illinois at Chicago
Anat Loewenstein, MD, Professor and Director, Department of Ophthalmology, Tel Aviv Medical Center
Carl D. Regillo, MD, FACS, FASRS, Chief of Retina Service, Wills Eye Hospital, Philadelphia, PA
Arshad Khanani, MD, MA FASRS, on a virtual call
At this year's ESCRS meeting, we asked presenters and attendees, 'What do yoou wish you'd known earlier in your ophthalmology career?'
Diana Do, MD, Professor of Ophthalmology, Byers Eye Institute, Stanford University, discusses the PHOTON study results as presented AAO
Penny A Asbell, MD, FACS speaks at the 2023 AAO meeting
© 2024 MJH Life Sciences

All rights reserved.