Glaucoma and blocked blood vessels

Article

A study reported in the July issue of Ophthalmology, the journal of the American Academy of Ophthalmology correlates the incidence of silent cerebral infarcts (SCI) and visual field loss in patients with normal-tension glaucoma.

A study reported in the July issue of Ophthalmology, the journal of the American Academy of Ophthalmology correlates the incidence of silent cerebral infarcts (SCI) and visual field loss in patients with normal-tension glaucoma.

Health conditions in normal tension glaucoma (NTG) patients differ from those in patients with the more common primary open-angle glaucoma (POAG). For one thing, an increased incidence of silent cerebral infarct (SCI), blockage in small blood vessels in the brain, is seen in brain scans of people with NTG. Also, visual field loss is often more rapid in NTG patients than in those with POAG. Researchers at The Chinese University of Hong Kong, led by Dexter Y.L. Leung, FRCS, recently investigated whether SCI might be directly related to rate of visual field loss in patients newly diagnosed with NTG.

They found that visual field loss was 61% more likely in NTG patients with SCI than in those without SCI. Computed tomography (CT) brain scans performed at the beginning of the study showed that of 286 study subjects with similar NTG disease factors, 64 had SCI and 222 did not. Patients' visual field status was assessed every four months over three years. Though this study was in newly diagnosed NTG patients and results could vary in patients who have been in treatment, the results raise important points.

"First, this study adds weight to the hypothesis that vascular factors are likely causes of NTG, along with intraocular pressure (IOP). Second, if additional studies confirm SCI as a risk factor for visual field loss, treatment to prevent SCI might slow disease progression in NTG patients. Third, brain scans of NTG patients to detect SCI might be deemed cost-effective. Since treating SCI is also known to prevent stroke, we may be talking about saving not only vision, but lives," said Dr Leung.

NTG is termed 'normal' because the IOP is lower than the point at which optic nerve damage is known to occur in POAG patients. Despite this 'normal' IOP, optic nerve damage does occur in NTG patients, who comprise about one-third of all people with glaucoma.

Recent Videos
Durga Borkar, MD, MMCi, discusses FAS inhibition with ONL-1204
Theodore Leng, MD, MS, speaks about 12-Month Real-World Clinical and Anatomical Outcomes With Faricimab in Patients With Diabetic Macular Edema:The FARETINA-DME Study
Rishi P. Singh, MD, discussed his presentation on the results from part 1 of the Phase 2/3 SIGLEC trial assessing AVD-104 for GA
Carl C. Awh, MD, FASRS, speaks with Hattie Hayes of Ophthalmology Times Europe
Carl J. Danzig, MD
Martin Zinkernagel, MD, PhD, speaks about the ASRS sustainability expert panel
Srinivas Sai Kondapalli, MD, discusses outer retinal tubulations in lesion growth for subfoveal and non-subfoveal GA
Jennifer I. Lim, MD, FARVO, FASRS
ARVO 2024: Andrew D. Pucker, OD, PhD on measuring meibomian gland morphology with increased accuracy
© 2024 MJH Life Sciences

All rights reserved.