Femtosecond laser finds new role for assisting cornea collagen cross-linking

Article

Creation of a pocket for intracorneal riboflavin instillation using the femtosecond laser (IntraLase, Advanced Medical Optics) appears to be a safe and effective method for assisting cornea collagen cross-linking.

Creation of a pocket for intracorneal riboflavin instillation using the femtosecond laser (IntraLase, Advanced Medical Optics) appears to be a safe and effective method for assisting cornea collagen cross-linking, said A. John Kanellopoulos, MD, at Refractive Surgery Subspecialty Day.

The technique, which Dr. Kanellopoulos has dubbed the "i-cornea tan," involves use of the laser to cut a 7-mm pocket at 100 µm corneal depth with a side cut of just 5 degrees. Then an air cannula is introduced into the pocket to instill the riboflavin 0.1% solution prior to UVA irradiation.

Dr. Kanellopoulos, medical director, Laservision Institute, Athens, Greece, reported using this procedure in 10 keratoconic eyes. Outcomes for mean reduction in keratometry and sphere achieved were comparable to those observed in eyes treated with the standard crosslinking technique. However, the new procedure was much more comfortable and associated with more rapid visual rehabilitation, he said. Endothelial cell counts were unchanged, and Dr. Kanellopoulos pointed out that the pocket creation does not have any adverse biomechanical effect on the cornea due to the minimal side cut.

"This technique provides a method for targeted delivery of riboflavin into the cornea at the depths where it is needed for crosslinking, and has several other advantages for the patient. Our initial experience must be validated with further studies and longer follow-up," Dr. Kanellopoulos said. "However, we believe this method has the potential to become the paradigm for preventing corneal transplantation in eyes with corneal ectasia."

Newsletter

Join ophthalmologists across Europe—sign up for exclusive updates and innovations in surgical techniques and clinical care.

Recent Videos
At the Retina World Congress, Siegfried Priglinger, MD, speaks about ensuring the best outcomes for preschool-aged patients
At the 2025 ASCRS meeting, Robert Ang, MD said small aperture IOLs can benefit all patients, especially those with complex corneas or who have undergone previous corneal refractive surgery
Viha Vig, MBChB graduate student at the University of Auckland, New Zealand, discusses her poster presentation on the relationship between mitochondiral disease, Alzheimer disease, and other types of dementia.
Alfredo Sadun, MD, PhD, chief of Ophthalmology at the Doheny Eye Institute, University of California Los Angeles, shared exciting new research with the Eye Care Network during the Association for Research in Vision and Ophthalmology (ARVO) meeting on the subject of Leber hereditary optic neuropathy (LHON).
At this year's Association for Research in Vision and Ophthalmology (ARVO) meeting in Salt Lake City, Utah, Nitish Mehta, MD, shared highlights from his research documenting real-world results of aflibercept 8 mg for patients with diabetic macular oedema.
ARVO 2025: Anat Loewenstein, MD, shares data from herself and her colleagues on meeting needs of patients with diabetic retinopathy
At the American Society of Cataract and Refractive Surgeons annual meeting, Sheng Lim, MD, FRCOphth discusses the benefit of endoscopic cyclophotocoagulation for patients with primary open angle glaucoma and cataracts in the CONCEPT study
A photo of Seville, Spain, with the Congress on Controversies in Ophthalmology logo superimposed on it. Image credit: ©francovolpato – stock.adobe.com; logo courtesy COPHy
Anat Loewenstein, MD, Professor and Director, Department of Ophthalmology, Tel Aviv Medical Center, discusses the Congress on Controversies in Ophthalmology (COPHy)
Anat Loewenstein, MD, speaks about the 22nd Annual Angiogenesis, Exudation, and Degeneration Meeting in February 2025 and shares her global forecast for AI-driven home OCT
© 2025 MJH Life Sciences

All rights reserved.