ECD not linked to CCT in keratoconus

Article

Corneal endothelial cell density (ECD) changes are independent from central corneal thickness (CCT) in keratoconus patients, states a recent paper.

Corneal endothelial cell density (ECD) changes are independent from central corneal thickness (CCT) in keratoconus patients, states a recent paper.

The cross-sectional controlled study, headed by Dr Ozgur Bulent Timucin, Van Training and Research Hospital, Department of Ophthalmology, Van, Turkey, prospectively assessed 65 keratoconus patients with no history of contact lens wear and 40 healthy control subjects. The Heidelberg Retinal Tomography Rostock Cornea Module (HRT3/RCM) was used to evaluate all eyes. The main outcome was the comparison of the average ECD from both groups.

The results revealed that 19 eyes had mild keratoconus, 21 had moderate keratoconus and 25 had severe keratoconus. The mean ECD was 2731.6 ± 303.2 cells/mm2 and 2664.9 ± 319.5 cells/mm2 in keratoconus patients and control subjects, respectively.

There were no differences betweens densities and no significant correlations between ECD and CCT or steepest keratometric. There were no changes in ECD in keratoconic patients without a history of contact lens use when compared to the healthy subjects.

Visit the Journal of the British Contact Lens Association.

Newsletter

Join ophthalmologists across Europe—sign up for exclusive updates and innovations in surgical techniques and clinical care.

Recent Videos
Christine Curcio, PhD, of the University of Alabama at Birmingham Heersink School of Medicine, shares histology update and revised nomenclature for OCT with Sheryl Stevenson of the Eye Care Network and Ophthalmology Times
SriniVas R. Sadda, MD, FARVO, shares key points from his retina presentation at the International SPECTRALIS Symposium
Robert Sergott, MD, describes fluorescence lifetime imaging ophthalmoscopy (FLIO) and the International SPECTRALIS Symposium – And Beyond (ISS) in Heidelberg, Germany.
Rayaz Malik, MBChB, PhD, a professor of medicine at Weill Cornell Medicine - Qatar, spoke with Ophthalmology Times Europe about his presentation. It's titled "An eye on neurodegenerative diseases: Challenging the dogma" at the International SPECTRALIS Sympsoium. In conversation with Hattie Hayes, Ophthalmology Times Europe
Anat Loewenstein, MD, describes her presentation on remote imaging for age-related macular degeneration and geographic atrophy at the International SPECTRALIS Symposium, in conversation with Hattie Hayes of Ophthalmology Times Europe
Tyson Brunstetter, OD, PhD, a US Navy Aerospace Optometrist at the NASA Johnson Space Center in Houston, Texas, shares key takeaways from his keynote at the International SPECTRALIS Symposium (ISS)
Rayaz Malik, MBChB, PhD, shares his presentation, titled An eye on neurodegenerative diseases: Challenging the dogma, at this year's International SPECTRALIS Symposium
At the Retina World Congress, Siegfried Priglinger, MD, speaks about ensuring the best outcomes for preschool-aged patients
At the 2025 ASCRS meeting, Robert Ang, MD said small aperture IOLs can benefit all patients, especially those with complex corneas or who have undergone previous corneal refractive surgery
Viha Vig, MBChB graduate student at the University of Auckland, New Zealand, discusses her poster presentation on the relationship between mitochondiral disease, Alzheimer disease, and other types of dementia.
© 2025 MJH Life Sciences

All rights reserved.