DSEK: the pros and cons

Article

DSEK: the pros and cons

Descemet's stripping with endothelial keratoplasty provides significant advantages over penetrating keratoplasty (PK), according to a study published in the March 2006 issue of the Journal of Cataract & Refractive Surgery.

The Price Vision Group, under the direction of Francis Price Jr., MD and Marianne Price, PhD, analysed the outcomes of 200 consecutive DSEK procedures, performed by the same surgeon, in order to establish early challenges associated with the method, as well as techniques required to promote donor tissue adherence.

The technique involved stripping Descemet's membrane and endothelium from the recipient's central cornea and transplanting an 8.0 to 9.0 mm disc of donor endothelium and posterior stroma through a 5.0 mm incision, with sutures used simply to close the incision. Follow-up was seven to 20 months for 124 eyes and two to six months for 76 eyes.

At the study's conclusion, the investigators admitted that the most frequent challenge was inadequate donor attachments. Any incidences of donor detachment were remedied by injecting an air bubble to press the donor against the recipient cornea. While there were seven primary graft failures, only one occurred in the second lot of 100 cases, which primarily used microkeratome-dissected donor tissue. Other, very rare, complications included papillary block glaucoma, cataract development and aqueous misdirection. However, DSEK was performed successfully following LASIK.

The authors concluded that DSEK did indeed offer certain advantages over PK, including more rapid healing, predictable refractive outcomes and enhanced corneal strength and integrity. Though the study group admitted donor adherence was slightly trickier, the procedure itself was technically easier and hence should be less traumatic to anterior chamber structures.

Newsletter

Join ophthalmologists across Europe—sign up for exclusive updates and innovations in surgical techniques and clinical care.

Recent Videos
Alfredo Sadun, MD, PhD, chief of Ophthalmology at the Doheny Eye Institute, University of California Los Angeles, shared exciting new research with the Eye Care Network during the Association for Research in Vision and Ophthalmology (ARVO) meeting on the subject of Leber hereditary optic neuropathy (LHON).
At this year's Association for Research in Vision and Ophthalmology (ARVO) meeting in Salt Lake City, Utah, Nitish Mehta, MD, shared highlights from his research documenting real-world results of aflibercept 8 mg for patients with diabetic macular oedema.
ARVO 2025: Anat Loewenstein, MD, shares data from herself and her colleagues on meeting needs of patients with diabetic retinopathy
At the American Society of Cataract and Refractive Surgeons annual meeting, Sheng Lim, MD, FRCOphth discusses the benefit of endoscopic cyclophotocoagulation for patients with primary open angle glaucoma and cataracts in the CONCEPT study
A photo of Seville, Spain, with the Congress on Controversies in Ophthalmology logo superimposed on it. Image credit: ©francovolpato – stock.adobe.com; logo courtesy COPHy
Anat Loewenstein, MD, Professor and Director, Department of Ophthalmology, Tel Aviv Medical Center, discusses the Congress on Controversies in Ophthalmology (COPHy)
(Image credit: Ophthalmology Times Europe) AGS 2025: Clemens Strohmaier, PhD, on improving aqueous humour outflow following excimer laser trabeculostomy
3 experts are featured in this series.
Anat Loewenstein, MD, speaks about the 22nd Annual Angiogenesis, Exudation, and Degeneration Meeting in February 2025 and shares her global forecast for AI-driven home OCT
3 experts are featured in this series.
Related Content
© 2025 MJH Life Sciences

All rights reserved.