Discrete macular cell layers correlated with visual sensitivity loss


Macular inner retinal layer (mIRL) is linked to visual sensitivity in glaucoma patients

Macular inner retinal layer (mIRL) is linked to visual sensitivity in glaucoma patients, according to a study featured in Eye.

A team led by Dr T. S. Varjaranant, Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago, Illinois, USA, compared the thickness of discrete macular cell layers, the thickness of the retinal nerve fibre layer (mRNFL) and visual field sensitivity between 28 glaucoma patients and 22 control patients. Stratus optical coherence tomography macular scans were used to measure thickness of macular retinal nerve fibre layer (mRNFL), macular inner retinal layer (mIRL) and macular outer retinal layer (mORL). Visual sensitivity loss was calculated by mean deviation (MD) using Humphrey Visual Field Analyser. To evaluate structure–function, a mixed model analysis was used.

The findings demonstrated that the mean mIRL thickness was significantly lower in advanced glaucoma than in the control group. Mean mIRL thickness was strongly linked to MD. There were no significant results recorded between mean mORL thickness in early and advanced glaucoma and the control group.

Although there was no difference in macular structure–function between advanced and early glaucoma, both glaucoma groups showed that mIRL thickness was related to visual sensitivity loss.

Related Videos
ARVO 2024: Andrew D. Pucker, OD, PhD on measuring meibomian gland morphology with increased accuracy
 Allen Ho, MD, presented a paper on the 12 month results of a mutation agnostic optogenetic programme for patients with severe vision loss from retinitis pigmentosa
Noel Brennan, MScOptom, PhD, a clinical research fellow at Johnson and Johnson
ARVO 2024: President-elect SriniVas Sadda, MD, speaks with David Hutton of Ophthalmology Times
Elias Kahan, MD, a clinical research fellow and incoming PGY1 resident at NYU
Neda Gioia, OD, sat down to discuss a poster from this year's ARVO meeting held in Seattle, Washington
Eric Donnenfeld, MD, a corneal, cataract and refractive surgeon at Ophthalmic Consultants of Connecticut, discusses his ARVO presentation with Ophthalmology Times
John D Sheppard, MD, MSc, FACs, speaks with David Hutton of Ophthalmology Times
Paul Kayne, PhD, on assessing melanocortin receptors in the ocular space
Osamah Saeedi, MD, MS, at ARVO 2024
© 2024 MJH Life Sciences

All rights reserved.