Corneal grafts from cancer patients more likely to cause infection

Article

Corneal grafts obtained from cancer patients may be associated with an increased risk of infection for the recipient, according to a study published in the February issue of Archives of Ophthalmology.

Corneal grafts obtained from cancer patients may be associated with an increased risk of infection for the recipient, according to a study published in the February issue of Archives of Ophthalmology.

Sohela Hassan and colleagues from the Baylor College of Medicine, Houston, USA, used data from a surveillance registry to determine whether the donor’s health status was associated with a risk of infection in the recipient. Donor information was collected for all cases of eye infection reported for transplants performed between 1994 and 2003.

During the study period, eye banks distributed 340,174 donor corneas in the US and 109,009 internationally. A total of 162 cases of endophthalmitis were reported. The odds of infected recipients having received a cornea from a hospitalized donor were three-times that of non-infected recipients. In addition, death of the donor from cancer was considerably more likely among recipients who developed infections. The cause is not yet clear, but donors may acquire harmful microorganisms in the hospital and transmit them to patients.

The results suggest that a donor’s health may affect their eye tissue, however, the authors do not recommend excluding broad categories of donors.

Related Videos
ARVO 2024: Andrew D. Pucker, OD, PhD on measuring meibomian gland morphology with increased accuracy
 Allen Ho, MD, presented a paper on the 12 month results of a mutation agnostic optogenetic programme for patients with severe vision loss from retinitis pigmentosa
Noel Brennan, MScOptom, PhD, a clinical research fellow at Johnson and Johnson
ARVO 2024: President-elect SriniVas Sadda, MD, speaks with David Hutton of Ophthalmology Times
Elias Kahan, MD, a clinical research fellow and incoming PGY1 resident at NYU
Neda Gioia, OD, sat down to discuss a poster from this year's ARVO meeting held in Seattle, Washington
Eric Donnenfeld, MD, a corneal, cataract and refractive surgeon at Ophthalmic Consultants of Connecticut, discusses his ARVO presentation with Ophthalmology Times
John D Sheppard, MD, MSc, FACs, speaks with David Hutton of Ophthalmology Times
Paul Kayne, PhD, on assessing melanocortin receptors in the ocular space
Osamah Saeedi, MD, MS, at ARVO 2024
© 2024 MJH Life Sciences

All rights reserved.