Corneal confocal microscopy is helpful in VKC

Article

Corneal confocal microscopy is useful for studying in vivo pathologic corneal changes in vernal keratoconjunctivitis (VKC).

Corneal confocal microscopy is useful for studying in vivo pathologic corneal changes in vernal keratoconjunctivitis (VKC), claims a study in the journal Ophthalmology.

Dr Andrea Leonardi et al., Department of Neuroscience, Ophthalmology Unit, University of Padova, Padova, Italy, completed a prospective, comparative case study on 32 patients with VKC and 40 normal participants.

All patients underwent a full ophthalmic examination and central cornea images were gathered using a x40 non-contact lens and a Z-ring device. The main outcome measures were the superficial and basal epithelium, subbasal nerve plexus, anterior stroma, stromal nerves and endothelium of the central cornea.

It was discovered that the VKC patients had increased diameter, reflectivity and presence of nuclear activation of superficial epithelial cells. They also had a reduced basal membrane density, an increased presence of activated keratocytes and inflammatory cells in the anterior stroma.

The VKC patients also presented with lower density and number of fibres, lower number of beadings and a higher grade of tortuosity of fibres in the subbasal nerve plexus. In the stromal corneal nerves there was an increased thickness, deflections and tortuosity changes.

The study authors concluded that the changes in the epithelium and subbasal and stromal corneal nerves could be linked to tear dysfunction and non-specific hyperactivity.

Related Videos
ARVO 2024: Andrew D. Pucker, OD, PhD on measuring meibomian gland morphology with increased accuracy
 Allen Ho, MD, presented a paper on the 12 month results of a mutation agnostic optogenetic programme for patients with severe vision loss from retinitis pigmentosa
Noel Brennan, MScOptom, PhD, a clinical research fellow at Johnson and Johnson
ARVO 2024: President-elect SriniVas Sadda, MD, speaks with David Hutton of Ophthalmology Times
Elias Kahan, MD, a clinical research fellow and incoming PGY1 resident at NYU
Neda Gioia, OD, sat down to discuss a poster from this year's ARVO meeting held in Seattle, Washington
Eric Donnenfeld, MD, a corneal, cataract and refractive surgeon at Ophthalmic Consultants of Connecticut, discusses his ARVO presentation with Ophthalmology Times
John D Sheppard, MD, MSc, FACs, speaks with David Hutton of Ophthalmology Times
Paul Kayne, PhD, on assessing melanocortin receptors in the ocular space
Osamah Saeedi, MD, MS, at ARVO 2024
© 2024 MJH Life Sciences

All rights reserved.