Using diclofenac sodium 0.1% and latanoprost 0.005% simultaneously could affect intraocular pressure (IOP) in glaucoma patients, according to a study published in the 

, Department of Ophthalmology, Nikookari Eye Center, Tabriz University of Medical Sciences, Iran, studied 22 patients with bilateral primary open angle glaucoma. Each patient was administered latanoprost for 4 weeks.

The patients were given topical diclofenac sodium in one eye and hydroxypropyl methyl cellulose was given in the other. This was completed 4 times a day for a fortnight. IOP was measured 2 weeks after treatment and 2 weeks after stopping other ophthalmic treatments.

The findings revealed additional administration of diclofenac sodium raised mean IOP from 15.73±1.75 to 17.32±2.23 mmHg. Two weeks after patients stopped using additional solutions, IOP was reduced. The control group did not show any significant difference in mean IOP. When co-administrating diclofenac sodium and latanoprost, the possibility of interference should be considered.

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Using diclofenac sodium 0.1% and latanoprost 0.005% simultaneously could affect intraocular pressure (IOP) in glaucoma patients