Combination treatment may affect IOP results.

Using diclofenac sodium 0.1% and latanoprost 0.005% simultaneously could affect intraocular pressure (IOP) in glaucoma patients, according to a study published in the Journal of Glaucoma.

Dr Rana Sorkhabi et al., Department of Ophthalmology, Nikookari Eye Center, Tabriz University of Medical Sciences, Iran, studied 22 patients with bilateral primary open angle glaucoma. Each patient was administered latanoprost for 4 weeks.

The patients were given topical diclofenac sodium in one eye and hydroxypropyl methyl cellulose was given in the other. This was completed 4 times a day for a fortnight. IOP was measured 2 weeks after treatment and 2 weeks after stopping other ophthalmic treatments.

The findings revealed additional administration of diclofenac sodium raised mean IOP from 15.73±1.75 to 17.32±2.23 mmHg. Two weeks after patients stopped using additional solutions, IOP was reduced. The control group did not show any significant difference in mean IOP. When co-administrating diclofenac sodium and latanoprost, the possibility of interference should be considered.