Combating serious infections

November 1, 2006

Acanthamoeba is a ubiquitous, free-living protozoan that rarely causes ocular disease other than troublesome keratitis.1-5 It remains restricted to the cornea, either because the trophozoites cannot penetrate Descemet's membrane and the corneal endothelium in order to enter the anterior chamber (AC), or the trophozoites are able to enter the anterior chamber but the cells of the innate immune apparatus prevent it from progressing to cause an intraocular infection.