Candida is the most common isolate of keratitis

Article

In a review of culture-positive fungal keratitis seen at Moorfields Eye Hospital, London, UK, over a 13-year period, Candida has been identified as the principal isolate.

In a review of culture-positive fungal keratitis seen at Moorfields Eye Hospital, London, UK, over a 13-year period, Candida has been identified as the principal isolate, according to the results of a study published in the October issue of Cornea.

Stephen Tuft and colleagues retrospectively identified isolates from laboratory reports and reviewed the clinical records. The fungal type, risk factors for infection, in vitro sensitivity and clinical outcome were recorded.

The researchers found 66 isolates from 65 patients, 40 of which were subspecies of Candida. The average interval from the onset of keratitis to confirmation of fungal infection was 3.4 weeks. Prior ocular surface disease or a penetrating keratoplasty (PK) was present in 97.4% of patients with Candida infection and 74.4% of patients with Candida infection were using topical steroids at the time of diagnosis.

The principal risk factors for filamentary fungal infection were trauma (30.8%) or cosmetic contact lens wear (30.8%), with ocular surface disease or a prior PK present in five (19.2%) cases.

The results of this review suggest that Candida is the principal isolate and is usually found in eyes with ocular surface disease or a prior PK treated with topical steroids.

Newsletter

Get the essential updates shaping the future of pharma manufacturing and compliance—subscribe today to Pharmaceutical Technology and never miss a breakthrough.

Recent Videos
Jeremiah Tao, MD, FACS, discusses his Egyptian Ophthalmological Society keynote, which focused on risk management and avoiding surgical complications in oculofacial surgery
Omer Trivizki, MD, MBA, a retina specialist from Tel Aviv Medical Center, speaks about VOY-101, a Novel, Complement-Modulating Gene Therapy for Geographic Atrophy at the American Society of Retina Specialists (ASRS) Annual Meeting
João Pedro Marques, MD, MSc, PhD discusses a retrospective study of 800 patients with inherited retinal diseases during the American Society of Retina Specialists (ASRS) annual meeting
© 2025 MJH Life Sciences

All rights reserved.