Association between the triglyceride-glucose index and central retinal artery occlusion

News
Article

The researchers reported a “notable” correlation which could serve as a predictive biomarker

An older woman sitting on a sofa measures her blood glucose by using a finger-prick blood test. Image credit: ©Prathankarnpap – stock.adobe.com

Significant differences in the TyG values were observed between the CRAO and control groups, the authors reported. Image credit: ©Prathankarnpap – stock.adobe.com

Researchers in Turkey, led by first author Hatice Aslan Sirakaya, MD, reported a “notable” association between an increased triglyceride-glucose (TyG) index and central retinal artery occlusion (CRAO).1 Dr Sirakaya is from the Department of Internal Medicine, Health Science University, The Kayseri City Hospital, Kayseri, Turkey. Investigators from the Department of Ophthalmology, Health Science University, The Kayseri City Hospital, and the Department of Ophthalmology, Maya Eye Hospital, both in Kayseri, joined in the study.

The investigators set out to identify a correlation between the TyG index in CRAO in patients who had been newly diagnosed with the disease.

The study included 51 patients and 50 healthy age- and sex-matched controls. All participants underwent an ocular examination and measurement of blood parameters. The TyG index was derived from fasting plasma glucose and triglyceride values. The average ages of the patients and controls were, respectively, 66.1 ± 8.9 and 64.9 ± 7.6 years.

The authors reported, “Significant differences in the TyG values were observed between the CRAO and control groups, with the CRAO group exhibiting higher values (8.74 ± 0.17 vs. 8.49 ± 0.22, P < 0.001).”

Multivariate analysis found that the TyG index was an independent predictor of CRAO (odds ratio = 1.84, 95% confidence interval = 1.19 – 4.23; P < 0.001). The area under the receiver operating curve for the TyG index was 0.789. A TyG index value over 8.58 predicted CRAO with 78% sensitivity and 68% specificity, the investigators reported.

They concluded that their data showed a notable association between the increased TyG index and CRAO. This finding indicated that the “TyG index could serve as a valuable predictive marker for assessing the risk of CRAO.”

Reference

Sirakaya HA, Ayyildiz B, Sert II, Kucuk B, Koca S, Sirakaya E. The role of triglyceride-glucose index in central retinal artery occlusion. Int Ophthalmol. 2025;45:82; https://doi.org/10.1007/s10792-024-03344-x

Newsletter

Join ophthalmologists across Europe—sign up for exclusive updates and innovations in surgical techniques and clinical care.

Recent Videos
Christine Curcio, PhD, of the University of Alabama at Birmingham Heersink School of Medicine, shares histology update and revised nomenclature for OCT with Sheryl Stevenson of the Eye Care Network and Ophthalmology Times
SriniVas R. Sadda, MD, FARVO, shares key points from his retina presentation at the International SPECTRALIS Symposium
Robert Sergott, MD, describes fluorescence lifetime imaging ophthalmoscopy (FLIO) and the International SPECTRALIS Symposium – And Beyond (ISS) in Heidelberg, Germany.
Rayaz Malik, MBChB, PhD, a professor of medicine at Weill Cornell Medicine - Qatar, spoke with Ophthalmology Times Europe about his presentation. It's titled "An eye on neurodegenerative diseases: Challenging the dogma" at the International SPECTRALIS Sympsoium. In conversation with Hattie Hayes, Ophthalmology Times Europe
Anat Loewenstein, MD, describes her presentation on remote imaging for age-related macular degeneration and geographic atrophy at the International SPECTRALIS Symposium, in conversation with Hattie Hayes of Ophthalmology Times Europe
Tyson Brunstetter, OD, PhD, a US Navy Aerospace Optometrist at the NASA Johnson Space Center in Houston, Texas, shares key takeaways from his keynote at the International SPECTRALIS Symposium (ISS)
Rayaz Malik, MBChB, PhD, shares his presentation, titled An eye on neurodegenerative diseases: Challenging the dogma, at this year's International SPECTRALIS Symposium
At the Retina World Congress, Siegfried Priglinger, MD, speaks about ensuring the best outcomes for preschool-aged patients
At the 2025 ASCRS meeting, Robert Ang, MD said small aperture IOLs can benefit all patients, especially those with complex corneas or who have undergone previous corneal refractive surgery
Viha Vig, MBChB graduate student at the University of Auckland, New Zealand, discusses her poster presentation on the relationship between mitochondiral disease, Alzheimer disease, and other types of dementia.
© 2025 MJH Life Sciences

All rights reserved.