An assessment of neovascular AMD activity

Article

Looking at an activity socring system to define lesions associated with wet AMD by quantifying their activity to determine the need for treatment.

Key Points

Inactive

Activity scoring system

The proposed ASS is based on the well-known and widely used signs and findings of active CNV:

Apart from FA staining pattern, all of the other assessments are based on the changes in each parameter (same-baseline/increased/decreased) and given a number to define the activity. At the end of the assessment, the numbers are totalled and an activity score is obtained.

Activity scores (AS) can range between 0 and 14. We believe that a CNV lesion with AS of 6–7 or more requires treatment and <6 does not. We are currently compiling a paper to more accurately determine the cut off AS to separate those lesions that need treatment and those that do not.

Newsletter

Get the essential updates shaping the future of pharma manufacturing and compliance—subscribe today to Pharmaceutical Technology and never miss a breakthrough.

Recent Videos
João Pedro Marques, MD, MSc, PhD discusses a retrospective study of 800 patients with inherited retinal diseases during the American Society of Retina Specialists (ASRS) annual meeting
Christine Curcio, PhD, of the University of Alabama at Birmingham Heersink School of Medicine, shares histology update and revised nomenclature for OCT with Sheryl Stevenson of the Eye Care Network and Ophthalmology Times
SriniVas R. Sadda, MD, FARVO, shares key points from his retina presentation at the International SPECTRALIS Symposium
© 2025 MJH Life Sciences

All rights reserved.