Anti-cataract agent discovered

January 25, 2011

An investigation, published in Inorganic Chemistry, has revealed that the reaction of pirenoxine (PRX) with selenite or calcium ions could be adapted as an anti-cataract agent.

An investigation, published in Inorganic Chemistry, has revealed that the reaction of pirenoxine (PRX) with selenite or calcium ions could be adapted as an anti-cataract agent. Seleneite and calcium ions have been associated with the formation of lens cataracts.

Dr Jiahn-Haur Liao, Institute of Biological Chemistry, Academia Sinica, Taiwan, ld the study that found theoretical evidence that the interactions most likely occur at the bezoquinone (ring I) π-system.

Isothermal titration calorimetry (ITC), UV and Nuclear magnetic resonance spectroscopy (NMR) were used to demonstrate that PRX can bind a maximum of six selenite anions.

Peripheral binding occurred first and was followed by the π−π interactions with the aromatic moiety. The calcium ions were chelated by the 3-carboxylate and 8-ketomine functional groups for calcium cation interaction.

The results could provide the foundation for further studies involving the use PRX as an anti-cataract agent.