AMT could stop ulceration

Amniotic membrane transplantation (AMT) may stop corneal ulceration and promote epithelialization, according to an investigation.

Dr Stanislav A. Iakimenko et al., Department of Eye Burns, Ophthalmic Plastic Surgery, Keratoplasty and Keratoprosthesis, State Institution,The Filatov Institute of Eye Diseases and Tissue Therapy of the NAMS of Ukraine, Ukraine, analysed the results of 55 AMTs in 53 eyes of 53 patients.

All patients had corneal ulceration and limbal deficiency 180-360° of the limbus after grade 4-6 chemical and thermal injuries was performed. The preoperative visual acuity (VA) was

The findings showed that corneal ulceration was prevented in 98.1% of cases and corneas were epithelialized in 76.3% of AMTs. Corneal defect recurred in 7.1% of successful cases and VA was ≥0.01 in 54.8% of patients after corneal epithelialization.

VA at the last follow-up visit improved on 2 or more lines on the eye chart, compared to preoperative VA in 35.7% with corneal epithelialization. VA didn’t improve in 42.9% of successful patients and it reduced by one line in 26.2% of patients.

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