ALTK & DSAEK offer fast visual recovery

Article

Automated lamellar therapeutic keratoplasty (ALTK) and Descemet stripping automated endothelial keratoplasty (DSAEK) are both safe and effective techniques for corneal transplantation.

Automated lamellar therapeutic keratoplasty (ALTK) and Descemet stripping automated endothelial keratoplasty (DSAEK) are both safe and effective techniques for corneal transplantation, according to Paolo Garimoldi and colleagues from Ospedale di Circolo, Italy.

Twenty eyes, 18 affected by keratocone and 2 by stromal opacity for herpes simplex keratitis, underwent ALTK. In eyes with keratocone, releasing penetrating stromal incisions were performed and a thicker graft obtained from a donor cornea, which was transplanted. The 18 eyes affected by Fuchs endothelial dystrophy underwent DSAEK; after removing the endothelium and Descemet membrane, a graft of deep stroma and endothelium from the donor cornea was inserted in the anterior chamber and positioned with an air-bubble.

Eyes treated with ALTK demonstrated very good graft transparency and an excellent quality of interface. No rejection reactions were noted and early temporary de-epithelialization occurred in 20% of cases. Best corrected visual acuity (BCVA) was 0.6 or better in 90% of subjects after three months follow-up. The eyes treated with DSAEK demonstrated a progressive increase of corneal transparency and the BCVA was 0.5 or better in 70% of cases after three months follow-up.

It was concluded that both procedures are safe and effective, particularly with regards the fast visual recovery and low level of complications.

Newsletter

Get the essential updates shaping the future of pharma manufacturing and compliance—subscribe today to Pharmaceutical Technology and never miss a breakthrough.

Recent Videos
Omer Trivizki, MD, MBA, a retina specialist from Tel Aviv Medical Center, speaks about VOY-101, a Novel, Complement-Modulating Gene Therapy for Geographic Atrophy at the American Society of Retina Specialists (ASRS) Annual Meeting
João Pedro Marques, MD, MSc, PhD discusses a retrospective study of 800 patients with inherited retinal diseases during the American Society of Retina Specialists (ASRS) annual meeting
Christine Curcio, PhD, of the University of Alabama at Birmingham Heersink School of Medicine, shares histology update and revised nomenclature for OCT with Sheryl Stevenson of the Eye Care Network and Ophthalmology Times
© 2025 MJH Life Sciences

All rights reserved.