Alcon releases new data for glaucoma candidate

Article

Alcon has announced positive efficacy and safety results from its second controlled proof of concept clinical study of anecortave acetate administered as an anterior juxtascleral depot in the sub-Tenon's space to reduce intraocular pressure (IOP) in patients with open-angle glaucoma.

Alcon has announced positive efficacy and safety results from its second controlled proof of concept clinical study of anecortave acetate administered as an anterior juxtascleral depot in the sub-Tenon's space to reduce intraocular pressure (IOP) in patients with open-angle glaucoma.

A total of 89 patients were enrolled and randomly assigned to receive either 7.5 mg of anecortave acetate dosed with 0.25 mL of 30 mg/mL suspension, 15 mg of anecortave acetate dosed with 0.5 mL of 30 mg/mL suspension or 0.5 mL of vehicle. One injection of the drug or vehicle was administered to each patient and IOP was assessed at two weeks, six weeks and three months, with month three predefined as the visit for primary efficacy.

The primary conclusion was that both the 7.5 mg and 15 mg doses of anecortave acetate demonstrated statistically significant lower mean IOP than vehicle at three months follow-up. Approximately 55% of patients in the 7.5 mg and the 15 mg arms were deemed successes at three months. This contrasts with the vehicle treatment group, where approximately 50% of patients were treatment failures by week two.

In terms of safety, the most frequently reported adverse events were related to the procedure and included eye pain, foreign body sensation, hyperaemia and blurred vision, which were reported at an incidence of 5 to 15%.

The study will continue with clinical assessments at six-week intervals.

Newsletter

Get the essential updates shaping the future of pharma manufacturing and compliance—subscribe today to Pharmaceutical Technology and never miss a breakthrough.

Recent Videos
Jeremiah Tao, MD, FACS, discusses his Egyptian Ophthalmological Society keynote, which focused on risk management and avoiding surgical complications in oculofacial surgery
Omer Trivizki, MD, MBA, a retina specialist from Tel Aviv Medical Center, speaks about VOY-101, a Novel, Complement-Modulating Gene Therapy for Geographic Atrophy at the American Society of Retina Specialists (ASRS) Annual Meeting
João Pedro Marques, MD, MSc, PhD discusses a retrospective study of 800 patients with inherited retinal diseases during the American Society of Retina Specialists (ASRS) annual meeting
© 2025 MJH Life Sciences

All rights reserved.