Xeno-free autologous cultivated limbal epithelial transplantation is effective

Article

Using xeno-free autologous cultivated limbal epithelial transplantation has proven to be effective in restoring corneal epithelial stability and improving vision in patients with ocular surface burns

Using xeno-free autologous cultivated limbal epithelial transplantation has proven to be effective in restoring corneal epithelial stability and improving vision in patients with ocular surface burns, according to a paper published in British Journal of Ophthalmology.

Dr Virender S. Sangwan et al., L V Prasad Eye Institute, Kallam Anji Reddy Campus, India, conducted a retrospective study on 200 patients with unilateral total limbal cell deficiency caused by ocular surface burns. Patients were treated between 2001 and 2010 and underwent a small limbal biopsy from the normal eye.

For 10 to 14 days limbal epithelial cells were expanded ex vivo on the human amniotic membrane. This was completed by using a xeno-free explant culture system. The patient's affected eye received cultured epithelial monolayer and amniotic membrane substrate transplantation. The outcome measures included postoperative corneal surface stability, visual improvement and complications.

Of the 200 eyes studied, 142 presented with a fully epithelised, avascular and clinically stable corneal surface with a mean follow-up of 3±1.6 years. In 121 eyes a two-line improvement in visual acuity was found.

The investigation has demonstrated the success of the limbal epithelial transplantation in restoring corneal epithelial stability in patients with ocular burns.

Related Videos
ARVO 2024: Andrew D. Pucker, OD, PhD on measuring meibomian gland morphology with increased accuracy
 Allen Ho, MD, presented a paper on the 12 month results of a mutation agnostic optogenetic programme for patients with severe vision loss from retinitis pigmentosa
Noel Brennan, MScOptom, PhD, a clinical research fellow at Johnson and Johnson
ARVO 2024: President-elect SriniVas Sadda, MD, speaks with David Hutton of Ophthalmology Times
Elias Kahan, MD, a clinical research fellow and incoming PGY1 resident at NYU
Neda Gioia, OD, sat down to discuss a poster from this year's ARVO meeting held in Seattle, Washington
Eric Donnenfeld, MD, a corneal, cataract and refractive surgeon at Ophthalmic Consultants of Connecticut, discusses his ARVO presentation with Ophthalmology Times
John D Sheppard, MD, MSc, FACs, speaks with David Hutton of Ophthalmology Times
Paul Kayne, PhD, on assessing melanocortin receptors in the ocular space
Osamah Saeedi, MD, MS, at ARVO 2024
© 2024 MJH Life Sciences

All rights reserved.