Unilateral RLB affects both eyes

Article

Laser burn to the retina of a single eye can compromise the immune privilege of the fellow eye.

Laser burn to the retina of a single eye can compromise the immune privilege of the fellow eye, concluded a study published in the February issue of the American Journal of Pathology.

Joan Stein-Streilein of Schepens Eye Research Institute, US and colleagues inflicted retinal laser burns (RLBs) on a single eye of 15 mice and injected both eyes with the antigen, Ovalbumin. Control mice, that had not been exposed to the laser burn, were also injected with Ovalbumin.

The immune privilege of both eyes was damaged six hours after RLB. This damage endured for up to 56 days. The control mice, however, experienced no inflammation, showing that the immune privilege of their eyes was not compromised. The team now intends to study the interactions between eyes to understand the novel mechanisms that allow for communication between the injured and non-injured eye.

Newsletter

Get the essential updates shaping the future of pharma manufacturing and compliance—subscribe today to Pharmaceutical Technology and never miss a breakthrough.

Recent Videos
Jay Chhablani, MD, shares late-breaking data from the ArMaDa trial, investigating gene therapy for Geographic Atrophy and dry age-related macular degeneration, at EURETINA
Editorial advisory board member Alexandra Miere, MD, PhD, speaks about the ACTOR and HERMES studies at the 2025 European Society of Retina Specialists (EURETINA) Congress
María Berrocal, MD, speaks about the Vit-Buckle Society symposium hosted at the 2025 European Society of Retina Specialists (EURETINA) annual meeting
© 2025 MJH Life Sciences

All rights reserved.