Unilateral RLB affects both eyes

Article

Laser burn to the retina of a single eye can compromise the immune privilege of the fellow eye.

Laser burn to the retina of a single eye can compromise the immune privilege of the fellow eye, concluded a study published in the February issue of the American Journal of Pathology.

Joan Stein-Streilein of Schepens Eye Research Institute, US and colleagues inflicted retinal laser burns (RLBs) on a single eye of 15 mice and injected both eyes with the antigen, Ovalbumin. Control mice, that had not been exposed to the laser burn, were also injected with Ovalbumin.

The immune privilege of both eyes was damaged six hours after RLB. This damage endured for up to 56 days. The control mice, however, experienced no inflammation, showing that the immune privilege of their eyes was not compromised. The team now intends to study the interactions between eyes to understand the novel mechanisms that allow for communication between the injured and non-injured eye.

Newsletter

Get the essential updates shaping the future of pharma manufacturing and compliance—subscribe today to Pharmaceutical Technology and never miss a breakthrough.

Recent Videos
Omer Trivizki, MD, MBA, a retina specialist from Tel Aviv Medical Center, speaks about VOY-101, a Novel, Complement-Modulating Gene Therapy for Geographic Atrophy at the American Society of Retina Specialists (ASRS) Annual Meeting
João Pedro Marques, MD, MSc, PhD discusses a retrospective study of 800 patients with inherited retinal diseases during the American Society of Retina Specialists (ASRS) annual meeting
Christine Curcio, PhD, of the University of Alabama at Birmingham Heersink School of Medicine, shares histology update and revised nomenclature for OCT with Sheryl Stevenson of the Eye Care Network and Ophthalmology Times
© 2025 MJH Life Sciences

All rights reserved.