Transporters delay diabetic retinal damage

Article

Two transporters that deliver alternative energy sources to the eye may help delay the retinal damage that occurs in diabetes.

Two transporters that deliver alternative energy sources to the eye may help delay the retinal damage that occurs in diabetes, according to researchers from the Medical College of Georgia, USA.

Pamela Martin and colleagues identified the two transporters, SMCT1 and SMCT2, which can circumvent the eye's protective blood-retinal barrier, delivering energy sources, lactate and ketone bodies, to a healthy eye. Dr Martin believes that the transporters "work harder" in diabetes to increase levels of lactate and ketone bodies, effectively slowing down the damage, which may explain why diabetes' impact on the eye can go undiagnosed for years.

Dr Martin has been awarded a Pathway to Independence Award from the US National Eye Institute that will help her to investigate the transporters' activity in health and diseased states. This work may help to enable early diagnosis of diabetic retinopathy and natural delivery mechanisms for drugs to prevent it.

Newsletter

Get the essential updates shaping the future of pharma manufacturing and compliance—subscribe today to Pharmaceutical Technology and never miss a breakthrough.

Recent Videos
Omer Trivizki, MD, MBA, a retina specialist from Tel Aviv Medical Center, speaks about VOY-101, a Novel, Complement-Modulating Gene Therapy for Geographic Atrophy at the American Society of Retina Specialists (ASRS) Annual Meeting
João Pedro Marques, MD, MSc, PhD discusses a retrospective study of 800 patients with inherited retinal diseases during the American Society of Retina Specialists (ASRS) annual meeting
Christine Curcio, PhD, of the University of Alabama at Birmingham Heersink School of Medicine, shares histology update and revised nomenclature for OCT with Sheryl Stevenson of the Eye Care Network and Ophthalmology Times
© 2025 MJH Life Sciences

All rights reserved.