Size and donor disparity influence IOP GAT

Larger grafts and greater donor-recipient disparity are factors influencing IOP measured with the Goldmann applanation tonometer (IOP GAT) after penetrating keratoplasty (PKP), according to a paper in the journal Cornea.

Dr S. Feizi et al., Ophthalmic Research Centre, Labbafinejad Medical Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran, conducted a cross-sectional study on 34 eyes of 34 keratoconus patients who had experienced penetrating keratoplasty (PKP).

At least six months postoperatively corneal hysteresis (CH), corneal resistance factor (CRF) and cornea-compensated intraocular pressure were measured. The independent t-test was used to compare two groups of donor-recipient disparity. Multivariate regression analysis was employed to assess the correlation of donor trephine size and central graft thickness (CGT) with the ocular response analyzer (ORA). The factors influencing IOP measured with the IOP GAT after PKP were identified using multiple regression analysis.

The findings revealed that mean CGT, CH and CRF were 564.7 ± 36.9 μm, 10.1 ± 2.1 mmHg, and 10.0 ± 2.3 mmHg, respectively. CH and CRF were positively correlated with donor trephine size and CGT, with significant values being observed in the 0.5 mm disparity group, opposed to the 0.25 mm disparity group.

The journal abstract can be found here