RNFL thickness linked to MS subtypes

Article

Thickness of the retinal nerve fibre layer (RNFL) correlates with the bicaudate ratio (BCR) and with subtypes of multiple sclerosis (MS), according to results from a recently published study.

Thickness of the retinal nerve fibre layer (RNFL) correlates with the bicaudate ratio (BCR) and with subtypes of multiple sclerosis (MS), according to results from a study published in the Journal of Neuro-Ophthalmology. In addition, they concluded that OCT is better suited for assessment of MS than scanning laser polarimetry with variable corneal compensation (GDx VCC).

Researchers set out to determine the association between RNFL thickness and brain atrophy using MRI with BCR in patients with MS with differing levels of disease severity, and assessed the what correlations - if any - existed between RNFL thickness and Expanded Disability Status Scale (EDSS) scores.

In all, they included 88 patients with MS and 59 age- and sex-matched health controls. Of these, 11 had clinically isolated syndrome (CIS), 68 had relapsing-remitting MS (RR-MS), and 9 had secondary progressive MS. All were evaluated using OCT and GDx VCC, and the same brain MRI scanning protocol was used in all of them. Disability was evaluated using the EDSS and BCR was calculated by dividing the minimum intercaudate distance by brain width along the same level.

BCR was higher in patients with MS compared with controls (0.12 vs 0.08, respectively; P P = 0.002). Researchers found significant correlations between average RNFL thickness and EDSS (r = –0.43; P = 0.003), as well as correlations between BCR and GDx parameters in patients with MS without optic neuritis.

"We conclude that the damage of retinal axons appears to be related to brain damage in patients with MS," the authors wrote.

For more information on this study, view the abstract here.

Newsletter

Join ophthalmologists across Europe—sign up for exclusive updates and innovations in surgical techniques and clinical care.

Recent Videos
Christine Curcio, PhD, of the University of Alabama at Birmingham Heersink School of Medicine, shares histology update and revised nomenclature for OCT with Sheryl Stevenson of the Eye Care Network and Ophthalmology Times
SriniVas R. Sadda, MD, FARVO, shares key points from his retina presentation at the International SPECTRALIS Symposium
Robert Sergott, MD, describes fluorescence lifetime imaging ophthalmoscopy (FLIO) and the International SPECTRALIS Symposium – And Beyond (ISS) in Heidelberg, Germany.
Rayaz Malik, MBChB, PhD, a professor of medicine at Weill Cornell Medicine - Qatar, spoke with Ophthalmology Times Europe about his presentation. It's titled "An eye on neurodegenerative diseases: Challenging the dogma" at the International SPECTRALIS Sympsoium. In conversation with Hattie Hayes, Ophthalmology Times Europe
Anat Loewenstein, MD, describes her presentation on remote imaging for age-related macular degeneration and geographic atrophy at the International SPECTRALIS Symposium, in conversation with Hattie Hayes of Ophthalmology Times Europe
Tyson Brunstetter, OD, PhD, a US Navy Aerospace Optometrist at the NASA Johnson Space Center in Houston, Texas, shares key takeaways from his keynote at the International SPECTRALIS Symposium (ISS)
Rayaz Malik, MBChB, PhD, shares his presentation, titled An eye on neurodegenerative diseases: Challenging the dogma, at this year's International SPECTRALIS Symposium
At the Retina World Congress, Siegfried Priglinger, MD, speaks about ensuring the best outcomes for preschool-aged patients
At the 2025 ASCRS meeting, Robert Ang, MD said small aperture IOLs can benefit all patients, especially those with complex corneas or who have undergone previous corneal refractive surgery
Viha Vig, MBChB graduate student at the University of Auckland, New Zealand, discusses her poster presentation on the relationship between mitochondiral disease, Alzheimer disease, and other types of dementia.
© 2025 MJH Life Sciences

All rights reserved.