Ranibizumab could cause GA progression in CNV

Ranibizumab injections could cause geographic atrophy (GA) progression in eyes with choroidal neovascularisation (CNV).

Dr Giuseppe Querques et al., Department of Ophthalmology, University Paris Est Creteil, Centre Hospitalier Intercommunal de Creteil, Paris, France, conducted a retrospective, interventional, consecutive case series on the charts of 21 eyes of 21 consecutive patients with GA caused by age-related macular degeneration (AMD). All patients were administered intravitreal ranibizumab injections for CNV at a minimum of 24 months earlier.

Best-corrected visual acuity (BCVA) significantly worsened at the 24-month follow-up visit and a significant increase of GA area was presented. However, there was a significant reduction in intraretinal cystic lesions, subretinal fluid and pigment epithelium detachment.

To read the abstract please visit the British Journal of Ophthalmology.