PDS + MMC = better results

Article

Augmenting combined phacoemulsification and deep sclerectomy (PDS) with intraoperative mitomycin C (MMC) is safe and likely to produce lower intraocular pressure (IOP) values than conducting PDS without MMC, according to the results of a study published in the August 2008 issue of Eye.

Augmenting combined phacoemulsification and deep sclerectomy (PDS) with intraoperative mitomycin C (MMC) is safe and likely to produce lower intraocular pressure (IOP) values than conducting PDS without MMC, according to the results of a study published in the August 2008 issue of Eye.

The research, which was initially presented as a poster at the 2005 meeting of the American Academy of Ophthalmology (AAO), was conducted by Seema Anand, FRCSEd of St James's University Hospital, Leeds, UK and Nitin Anand, FRCOphth of Huddersfield Royal Infirmary, Huddersfield, UK. The team conducted a retrospective, non-randomized, comparative case study of eyes undergoing PDS with (n=63) and without (n=56) MMC augmentation. The study period was from September 2001 to April 2004, with a mean follow-up period of 23 months (range: 12–41 months).

Two years postoperatively, the team calculated that subjects in the PDS with MMC augmentation group had a 76% likelihood of maintaining IOP of 19–15 mmHg without glaucoma medication; without needle revision, the likelihood was 62%. For the PDS without MMC group, these probabilities were 62% and 45%, respectively. For the non-MMC group, Nd:YAG laser goniopuncture and needle revision were required in 71.4% and 21.4% of cases, respectively. Nd:YAG laser goniopuncture and needle revision were required for 61.9% and 17.4%, respectively, of patients treated with MMC. For MMC treatment and no-MMC treatment, transconjunctival oozing was noted in 9.5% and 5.4%, respectively. Across both groups, 8.4% of subjects (n=10) lost two lines during the follow-up period; there was no statistically significant difference between the two groups.

The team concluded that the use of MMC to augment PDS is safe and likely to increase the likelihood of achieving a lower target IOP.

Newsletter

Join ophthalmologists across Europe—sign up for exclusive updates and innovations in surgical techniques and clinical care.

Recent Videos
At the Retina World Congress, Siegfried Priglinger, MD, speaks about ensuring the best outcomes for preschool-aged patients
At the 2025 ASCRS meeting, Robert Ang, MD said small aperture IOLs can benefit all patients, especially those with complex corneas or who have undergone previous corneal refractive surgery
Viha Vig, MBChB graduate student at the University of Auckland, New Zealand, discusses her poster presentation on the relationship between mitochondiral disease, Alzheimer disease, and other types of dementia.
Alfredo Sadun, MD, PhD, chief of Ophthalmology at the Doheny Eye Institute, University of California Los Angeles, shared exciting new research with the Eye Care Network during the Association for Research in Vision and Ophthalmology (ARVO) meeting on the subject of Leber hereditary optic neuropathy (LHON).
At this year's Association for Research in Vision and Ophthalmology (ARVO) meeting in Salt Lake City, Utah, Nitish Mehta, MD, shared highlights from his research documenting real-world results of aflibercept 8 mg for patients with diabetic macular oedema.
ARVO 2025: Anat Loewenstein, MD, shares data from herself and her colleagues on meeting needs of patients with diabetic retinopathy
At the American Society of Cataract and Refractive Surgeons annual meeting, Sheng Lim, MD, FRCOphth discusses the benefit of endoscopic cyclophotocoagulation for patients with primary open angle glaucoma and cataracts in the CONCEPT study
A photo of Seville, Spain, with the Congress on Controversies in Ophthalmology logo superimposed on it. Image credit: ©francovolpato – stock.adobe.com; logo courtesy COPHy
Anat Loewenstein, MD, Professor and Director, Department of Ophthalmology, Tel Aviv Medical Center, discusses the Congress on Controversies in Ophthalmology (COPHy)
(Image credit: Ophthalmology Times Europe) AGS 2025: Clemens Strohmaier, PhD, on improving aqueous humour outflow following excimer laser trabeculostomy
© 2025 MJH Life Sciences

All rights reserved.